ArticleAnimal models and experimental medicine2026
Ligand-complex-based quantification of β2-integrin-mediated affinity and avidity of murine T cells.
Article in Animal models and experimental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundIntegrins facilitate binding to the extracellular matrix and other cells. Their subunit β2 is exclusively expressed by leukocytes, binds to the intercellular cell adhesion molecule 1 (ICAM-1), and is pivotal for their recruitment to sites of inflammation such as the atherosclerotic plaque.
methodsTo investigate β2-integrin-mediated adhesiveness, a well-established assay for human whole blood was adapted for the analysis of murine T cell subsets. Changes in avidity and affinity were assessed by incubation of murine complexes ICAM-1 in murine whole blood and consecutive stimulation with PMA and Mg
resultsIncubation of murine whole blood with PMA leads to 30-fold and Mg
conclusionsOur assay allows specific quantification of β2-integrin-mediated affinity and avidity of T cells in whole blood samples. In congruence to human adhesion, these mechanisms are ROS and Ca
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