Evidence map›Paper›PMID 41742610›Full record

ArticleCurrent neurovascular research2026

Intraoperative Diabetes Insipidus as a Predictor of Postoperative Complications Following Revascularization in Moyamoya Disease: A Retrospective Cohort Study.

Jia Lu, Qian Chen, Xin Zhang, Yan-Jiang Li, Shao-Xuan Yang, Han-Qiang Jiang, Wei Ni, Chao Gao, Yu Lei, Jie Zhang and 1 more

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Article in Current neurovascular research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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11 authors.

Jia LuDepartment of Anesthesia, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Qian ChenDepartment of Anesthesia, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Xin ZhangDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Yan-Jiang LiDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Shao-Xuan YangDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Han-Qiang JiangDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Wei NiDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Chao GaoDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Yu LeiDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Jie ZhangDepartment of Anesthesia, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Yu-Xiang GuDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSurgical revascularization represents an effective treatment for moyamoya disease (MMD); however, it is associated with postoperative complications such as stroke and hyperperfusion syndrome. Intraoperative polyuria and electrolyte disturbances resembling diabetes insipidus (DI) are frequently observed, yet their clinical significance remains unclear. This study aimed to identify potential risk factors for postoperative complications and to evaluate the predictive value of intraoperative DI in individuals undergoing revascularization for MMD.

methodsA retrospective analysis was conducted on 273 consecutive revascularization procedures performed at the North Campus of Huashan Hospital between November 2019 and December 2022. Univariate and multivariate logistic regression analyses were used to identify independent risk factors of postoperative complications occurring within 30 days. Risk factors for intraoperative DI were assessed, and a nomogram-based predictive model was constructed.

resultsPostoperative hyperperfusion syndrome occurred in 106 cases (42.4%), and postoperative stroke in 20 cases (8.0%). Intraoperative DI was observed in 113 cases (45.2%). The incidence of postoperative complications was significantly higher among individuals who experienced intraoperative DI compared to those who did not (p = 0.02). Multivariate analysis identified intraoperative DI (p = 0.011), elevated body mass index (BMI) (p = 0.032), and ischemic MMD (p = 0.015) as independent risk factors for postoperative complications. In addition, high BMI was associated with an increased risk of intraoperative DI. The predictive model demonstrated good performance with an area under the curve of 0.798. DISCUSSION: This study highlights intraoperative DI, elevated BMI, and ischemic-type MMD as independent predictors of postoperative complications. The link between high BMI and DI suggests a potential interaction. Incorporating these factors into perioperative assessment may improve risk stratification and guide preventative strategies to enhance surgical outcomes in MMD patients.

conclusionThe association between high BMI and intraoperative DI indicates a potential predictive relationship, which may support perioperative risk stratification in individuals with MMD.

Indexed as

Cerebral RevascularizationDiabetes InsipidusIntraoperative ComplicationsMoyamoya DiseasePostoperative ComplicationsAdolescentAdultFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsYoung AdultBMIElectrolyte homeostasisintraoperative diabetes insipidusMoyamoya diseasepostoperative complicationsrisk factor

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PMID41742610

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.