ArticleJournal of veterinary internal medicine2026
Autoimmune lymphoproliferative syndrome in Boerboel dogs: treatment, clinical outcomes and prevention.
Article in Journal of veterinary internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Autoimmune lymphoproliferative syndrome in Boerboel dogs: clinicopathologic, diagnostic, and genetic characterization.Journal of veterinary internal medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAutoimmune lymphoproliferative syndrome (ALPS) is a rare genetic disorder caused by defective Fas cell surface death receptor-mediated lymphocyte apoptosis, resulting in chronic lymphadenomegaly, splenomegaly, and autoimmune cytopenias. Management of ALPS in dogs has not been reported previously. HYPOTHESIS/
objectivesDescribe treatment, therapeutic drug monitoring (TDM), and clinical and laboratory outcomes in Boerboel dogs with genetically confirmed ALPS. ANIMALS: Four affected Boerboel pups from a litter studied prospectively and 2 retrospectively identified littermates from a different litter.
methodsProspective case series. All 4 index puppies received prednisolone and proprietary sirolimus; 3 subsequently received generic sirolimus. Clinical response was assessed through physical examinations, CBCs, serum biochemistry profiles, and TDM. Two additional affected dogs were reviewed retrospectively.
resultsInitiation of proprietary sirolimus in the index litter was associated with resolution or near resolution of lymphadenomegaly and abdominal distension, improvement in hematologic variables, and decreased corticosteroid requirements. Gastrointestinal signs improved but recurred intermittently in pups 1 and 4. By 10 months of age, pups 2 and 3 achieved sustained, marked clinical improvement. Notably, pup 2 had all drugs discontinued and remained clinically well. A fourteen-month follow-up showed sustained overall clinical improvement in the index litter. CONCLUSIONS AND CLINICAL IMPORTANCE: Autoimmune lymphoproliferative syndrome can cause clinically relevant morbidity in dogs. Sirolimus, alone or with prednisolone, appeared effective and well tolerated, decreasing corticosteroid requirements and adverse effects. Genetic screening and management with sirolimus focused on patient comfort were beneficial. Clinical signs appeared to improve with age in some individuals, suggesting that de-escalation or discontinuation of treatment may be possible in selected cases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.