ArticleJournal of veterinary internal medicine2026
Hypertrophic cardiomyopathy is not the sole echocardiographic phenotype associated with hyperthyroidism in cats: a retrospective study in 147 cats (2005-2025).
Article in Journal of veterinary internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundA hypertrophic cardiomyopathy phenotype (HCMP) can occur in cats with hyperthyroidism. However, it remains unclear whether other cardiomyopathy phenotypes are also associated with hyperthyroidism in cats. HYPOTHESIS/
objectivesDescribe the epidemiological, clinical, and echocardiographic findings and cardiomyopathy phenotypes in a large sample of hyperthyroid cats. Compare the echocardiographic features of hyperthyroid cats with HCMP to those of a contemporaneous sample of normotensive euthyroid cats with primary hypertrophic cardiomyopathy (HCM). ANIMALS: A total of 147 hyperthyroid cats and 112 cats with primary HCM.
methodsRetrospective study with review of internal medicine and cardiology service databases (2005-2025).
resultsMost hyperthyroid cats (117/147, 80%) exhibited 1 of the 3 cardiomyopathy phenotypes: HCMP (94/147, 64%), restrictive cardiomyopathy phenotype (RCMP; 20/147, 14%), or nonspecific (3/147, 2%). Hyperthyroid cats with RCMP had significantly higher total thyroxine concentrations (median, 154 nmol/L vs 95 nmol/L) and more dyspnea related to congestive heart failure (80% vs 11%) than those with HCMP (P < .01). A gallop sound was detected in 10% of hyperthyroid cats (14/147), exclusively in those with HCMP (10%, 9/94) or RCMP (25%, 5/20). The end-diastolic left ventricular diameter was higher in hyperthyroid cats with HCMP than in those with primary HCM (P < .01). Subaortic septal hypertrophy was more frequent (95% vs 67%) in cats with primary HCM than in those with hyperthyroidism-associated HCMP (P < .01). CONCLUSIONS AND CLINICAL IMPORTANCE: The HCMP is the predominant, but not sole, echocardiographic phenotype observed in hyperthyroid cats. The RCMP is the second most frequent phenotype and may reflect a more severe form of hyperthyroidism.
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