ArticleJournal of veterinary internal medicine2026
Efficacy of tylosin phosphate for liver abscess control in feedlot cattle, by treatment duration: a Bayesian network meta-analysis supported by a randomized trial.
Article in Journal of veterinary internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Association of origin, performance, and health metrics of beef-on-dairy feedyard cattle with liver abscess at harvest.Translational animal science · 2026Article
- Economic costs of liver abscesses in U.S. beef feedlot cattle: a comprehensive economic analysis.Journal of animal science · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundTylosin phosphate feed supplementation is the most common method used to control liver abscesses (LAs) in US feedlot cattle, but reducing antimicrobial exposures is critical. HYPOTHESIS/
objectivesWe conducted a 2-phase study, using a randomized controlled trial designed to supplement a Bayesian network meta-analysis (NMA) to test bioequivalence of different durations of tylosin supplementation for the control of A+ LA's. ANIMALS: Sixteen thousand three hundred sixty-eight feedlot cattle.
methodsA randomized controlled trial evaluated 4 treatment groups and was interpreted within an NMA. The treatment groups included no tylosin supplementation (negative control), tylosin supplemented throughout the finishing period (Continuous), withdrawing tylosin 84 d before harvest (-84WD), or 56 d before harvest (-56WD). A total of 16 728 animals were randomly allocated in a 1:1:2:2 ratio, respectively. Thirty-two controlled studies with 72 086 enrolled animals, featuring 10 interventions, were incorporated into the NMA.
resultsContinuous cattle had reduced odds of severe (A+) LAs compared to NC cattle in the randomized trial (odds ratio = 0.75; 95% CI, 0.51-1.11). The NMA suggested tylosin use was superior in reducing LAs when compared to untreated cattle. However, early withdrawal did not have equivalent efficacy compared to continuous use. CONCLUSIONS AND CLINICAL IMPORTANCE: This investigation successfully merged a systematic review, NMA, and a primary trial to optimize fiscal and animal resources in a major research investigation.
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