ArticleJournal of veterinary internal medicine2026
Development and validation of the Chiari-like malformation and syringomyelia evaluation: the CHASE questionnaire.
Article in Journal of veterinary internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Owner Observed Sleep Disturbances in Cavalier King Charles Spaniels with and Without Clinical Signs Compatible with a Chiari-like Malformation.Animals : an open access journal from MDPI · 2026Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundChiari-like malformation (CM) and syringomyelia (SM) in dogs are associated with signs of neuropathic pain and itch, which are difficult to quantify reliably. HYPOTHESIS/
objectivesDevelop and validate the Chiari-like malformation and syringomyelia evaluation (CHASE) questionnaire to quantify owners' assessments of clinical signs of CM/SM in their dogs. ANIMALS: Twenty client-owned healthy dogs and 30 CM/SM affected dogs.
methodsThe CHASE questionnaire was developed using an iterative sampling design, reliability and normal scores were established in healthy dogs. A double-blinded, randomized, crossover study design was conducted using pregabalin and placebo, with CHASE as the primary outcome. Physical and neurologic examinations, activity monitors, quantitative sensory testing (QST), and quality of life assessments (QOL) were performed alongside the CHASE questionnaire at each time point.
resultsBaseline CHASE scores were significantly higher in CM/SM dogs compared with healthy dogs (15.3 ± 4.8 vs. 1.4 ± 1.8; P < .01), with score ranges of 6-24 and 0-6, respectively. The CHASE scores in CM/SM dogs were moderately repeatable from screening (15.1 ± 4.4) to baseline (15.1 ± 4.7) and decreased significantly with pregabalin compared with baseline and placebo (P < 0.001 and P < 0.03). The questionnaire had strong internal consistency (α = 0.89) and differentiated pregabalin from placebo with 63% sensitivity and 76% specificity (area under the curve = 0.67). No significant differences in QOL, QST, or activity levels were identified. CONCLUSIONS AND CLINICAL IMPORTANCE: We validated the use of the CHASE questionnaire to quantify clinical signs associated with CM/SM and distinguish treatment outcomes when other assessments failed.
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