ArticleJournal of veterinary internal medicine2026
Correlation of urine ammonia excretion with renal function in healthy dogs and dogs with chronic kidney disease.
Article in Journal of veterinary internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Association of impaired ammonia excretion with survival in dogs with stable chronic kidney disease.Journal of veterinary internal medicine · 2026Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundInadequate ammonia excretion is thought to drive the development of metabolic acidosis in people with chronic kidney disease (CKD) and correlates with worse clinical outcomes, such as faster progression to end-stage kidney disease and increased case fatality. HYPOTHESIS/
objectivesTo determine if urine ammonia-to-creatinine ratio (UACR) correlates with serum creatinine concentration as a renal function marker in healthy dogs and dogs with CKD and whether UACR is altered in the presence of CKD. ANIMALS: The study group comprised 46 healthy and 50 stable International Renal Interest Society (IRIS) Stages 2, 3, and 4 CKD dogs.
methodsThis was a prospective, single-time point study. Serum biochemistry variables were measured. Urinary ammonia and creatinine concentrations were measured and used to calculate UACR. Group comparisons were made with the Mann-Whitney test. Correlation between UACR and serum renal and electrolyte values was assessed using Spearman's correlation test. Relationships between UACR, renal variables, electrolytes, urine specific gravity, age, and body weight were explored with multiple linear regression.
resultsCKD dogs had lower UACR (median 2.2; range 0.9-10.5) than healthy dogs (median 7.1; range 0.7-40.0) (P < .001). UACR was inversely correlated with creatinine concentrations (P < .001, rs = -0.535). The relationship between UACR and creatinine persisted after controlling for age, body weight, electrolytes, renal functional variables, and urine specific gravity. CONCLUSIONS AND CLINICAL IMPORTANCE: These findings suggest that ammonia excretion is impaired in dogs with diminished renal function.
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