ArticleBiotechnology and applied biochemistry2026
Biosynthesis and Characterization of Zinc Oxide-Doped Selenium Nanocomposite Conjugated With l-Asparaginase Against Human Hepatoma Cell Line.
Article in Biotechnology and applied biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanocarriers have emerged as promising systems for improving drug-delivery efficiency and advancing diagnostic strategies in cancer treatment. l-asparaginase has well-established antitumor and anti-leukemic properties, but its therapeutic performance is often restricted due to its short biological half-life and poor instability in the unmodified form. The present study investigated the encapsulation of l-asparaginase on a green-synthesized nanocarrier to enhance its overall therapeutic efficacy. The nanocarrier was produced utilizing citrus orange peel extract, which served simultaneously as a reducing, stabilizing, and capping material during the formation of zinc oxide-doped selenium nanoparticles (ZnO-Se-NPs). This eco-friendly synthesis method not only stabilized the nanoparticles but also incorporated naturally occurring phytochemicals, including flavonoids, phenolic compounds, ascorbic acid, and carotenoids-that may contribute to additional pharmacological benefits. The synthesized l-asparaginase encapsulated ZnO-Se-NPs (ZnO-Se-Asp) nanocomposite exhibited notable anticancer activity while maintaining low cytotoxicity. The detailed characterization of the nanoparticles was carried out utilizing UV-Vis spectroscopy to confirm the presence of ZnO-Se-Asp, energy dispersive x-ray (EDX), and scanning electron microscope (SEM) for morphological and elemental analysis. The Fourier transform infrared spectroscopy (FTIR) was studied to identify the functional groups, and x-ray diffraction (XRD) was performed to study the crystallinity of synthesized ZnO-Se-Asp nanocomposite. The cytotoxic potential of synthesized ZnO-Se-Asp nanocomposite was estimated using the methyl thiazolyl tetrazolium (MTT) assay through the determined IC
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.