Evidence map›Paper›PMID 41742461›Full record

ArticleOncoimmunology2026

TNF-α deficiency underlies NK cell dysfunction in colorectal cancer.

Silvia Ruggeri, Beatrice Pizzitola, Mattia Laffranchi, Laura Beltrame, Giuseppe Sciumé, Alessio Grimaldi, Enrico Fiori, Roberto Caronna, Valerio De Peppo, Gian Luca Grazi and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncoimmunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Silvia RuggeriDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Beatrice PizzitolaDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Mattia LaffranchiDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Laura BeltrameKatholieke Universiteit Leuven, Leueven, Belgium.
Giuseppe SciuméDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Alessio GrimaldiDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Enrico FioriDepartment of Surgery, Sapienza University of Rome, Umberto I Polyclinic of Rome, Rome, Italy.
Roberto CaronnaDepartment of Surgery, Sapienza University of Rome, Umberto I Polyclinic of Rome, Rome, Italy.
Valerio De PeppoGeneral Surgery and Organ Transplantation Unit, Sapienza University of Rome, Umberto I Polyclinic of Rome, Rome, Italy.
Gian Luca GraziDepartment of Experimental and Clinical Medicine, Hepatobiliary Pancreatic Surgery, University of Florence, Florence, Italy.
Valentina LaquintanaPathology Department, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Giulia TurriDivision of General and Hepatobiliary Surgery, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy.
Silvano SozzaniDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Angela GismondiDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Cinzia FiondaDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Angela SantoniDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Helena StabileDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural killer (NK) cells are central to innate antitumor immunity, yet their function is systemically compromised in colorectal cancer (CRC). We show that CRC patients exhibit early and pronounced alterations in peripheral blood NK cells, marked by a reduced frequency of total CD56⁺ cells, a shift toward the CD56

Indexed as

colorectal cancercytokine signallingInnate ImmunityNK cellsTNF-α

Identifiers

PMID41742461
PMCPMC12940107

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.