Evidence map›Paper›PMID 41742403›Full record

ArticleCell reports. Medicine2026

Hierarchically collapsible nanoactuator modulates mitochondrial ferroptosis-bioenergetic homeostasis cascade to decouple ischemic stroke.

Guangjie Sun, Yize Dong, Ying Wang, Yihong Su, Jiajun Chen, Jiali Deng, Lan Luo, Xinyue Cao, Weiping Lu, Kai Chen and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Guangjie SunDepartment of Radiology, Gongli Hospital of Shanghai Pudong New Area, Shanghai 200135, China; School of Gongli Hospital Medical Technology, University of Shanghai for Science and Technology, Shanghai 200093, China.
Yize DongDepartment of Radiology, Gongli Hospital of Shanghai Pudong New Area, Shanghai 200135, China; School of Gongli Hospital Medical Technology, University of Shanghai for Science and Technology, Shanghai 200093, China.
Ying WangDepartment of Radiology, Gongli Hospital of Shanghai Pudong New Area, Shanghai 200135, China.
Yihong SuDepartment of Radiology, Gongli Hospital of Shanghai Pudong New Area, Shanghai 200135, China; School of Gongli Hospital Medical Technology, University of Shanghai for Science and Technology, Shanghai 200093, China.
Jiajun ChenDepartment of Radiology, Gongli Hospital of Shanghai Pudong New Area, Shanghai 200135, China; School of Gongli Hospital Medical Technology, University of Shanghai for Science and Technology, Shanghai 200093, China.
Jiali DengDepartment of Radiology, Gongli Hospital of Shanghai Pudong New Area, Shanghai 200135, China; School of Gongli Hospital Medical Technology, University of Shanghai for Science and Technology, Shanghai 200093, China.
Lan LuoDepartment of Radiology, Gongli Hospital of Shanghai Pudong New Area, Shanghai 200135, China; School of Gongli Hospital Medical Technology, University of Shanghai for Science and Technology, Shanghai 200093, China.
Xinyue CaoDepartment of Radiology, Gongli Hospital of Shanghai Pudong New Area, Shanghai 200135, China.
Weiping LuDepartment of Radiology, Gongli Hospital of Shanghai Pudong New Area, Shanghai 200135, China.
Kai ChenDepartment of Radiology, Gongli Hospital of Shanghai Pudong New Area, Shanghai 200135, China.
Meihua YuMaterdicine Lab, School of Life Sciences, Shanghai University, Shanghai 200444, China. Electronic address: myu@shu.edu.cn.
Yujie XieSchool of Medicine, Shanghai University, Shanghai 200444, China. Electronic address: xieyj@shu.edu.cn.
Bingcang HuangDepartment of Radiology, Gongli Hospital of Shanghai Pudong New Area, Shanghai 200135, China. Electronic address: hbc01275@glhospital.com.
Yu ChenMaterdicine Lab, School of Life Sciences, Shanghai University, Shanghai 200444, China; School of Medicine, Shanghai University, Shanghai 200444, China; Shanghai Institute of Materdicine, Shanghai 200052, China. Electronic address: chenyuedu@shu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic stroke, a life-altering cerebrovascular emergency triggered by prolonged cerebral hypoperfusion, remains a therapeutic enigma. Current interventions struggle with ischemia-reperfusion injury; restoring blood flow unleashes reactive oxygen species (ROS), driving secondary neuronal damage and functional loss. Ischemia-induced mitochondrial dysfunction heightens oxidative stress and hastens neuronal death. We address oxidative-stress-driven neuronal injury by engineering a hierarchically collapsible nanoactuator suppressing mitochondrial ferroptosis and restoring cellular energy homeostasis. The nanoactuator integrates a diselenide-crosslinked shell conjugated with a mitochondrial-targeting peptide, enabling blood-brain barrier penetration and mitochondrial delivery. Its collapsible core, composed of an ATP-gadolinium coordination polymer encapsulating a ferroptosis inhibitor, enables MRI-guided tracking and ROS-responsive drug release. In damaged mitochondria, the nanoactuator replenishes ATP, restores membrane potential, reduces ROS levels, and alleviates ferroptosis. Intravenous administration in a transient middle cerebral artery occlusion (tMCAO) mouse model demonstrated robust multi-mechanistic neuroprotection. This hierarchical nanoactuator platform offers a strategy for ischemic stroke and related neurodegenerative diseases.

Indexed as

Energy MetabolismFerroptosisHomeostasisIschemic StrokeMitochondriaAnimalsBrain IschemiaHumansInfarction, Middle Cerebral ArteryMaleMiceMice, Inbred C57BLOxidative StressReactive Oxygen SpeciesReactive Oxygen Speciesenergetic homeostasisferroptosisischemia-reperfusion injuryischemic strokenanoactuatoroxidative stress

Identifiers

PMID41742403
PMCPMC13006402

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.