ArticleJournal of oral rehabilitation2026
Repeated Unstimulated Whole Saliva Collection: A Reliable Approach to Improve Diagnostic Accuracy.
Article in Journal of oral rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
backgroundUnstimulated whole saliva (UWS) sialometry is fundamental for diagnosing salivary gland hypofunction, but single-timepoint measurements are limited by physiological variability.
objectiveTo evaluate intraindividual variability and reproducibility of a repeated-measures UWS collection protocol in healthy young adults, and to propose a standardised approach to improve diagnostic accuracy.
methodsSixty-two healthy subjects (19-33 years old) collected UWS by passive drooling three times daily (morning, afternoon and evening) over three consecutive days (nine timepoints). Data were analysed using linear mixed-effects models, intraclass correlation coefficients (ICC), Bland-Altman plots and coefficients of variation (CV%).
resultsMean UWS flow rate collected over 5 min remained stable across days (0.38-0.39 mL/min), ranging from 0.14 to 0.93 mL/min. Aggregated daily means showed the highest reproducibility (ICC
conclusionSingle UWS measurements are influenced by substantial physiological variability, which may lead to diagnostic misclassification. Averaging multiple standardised collections, particularly in the evening, enhances reliability and may optimise diagnostic accuracy. This protocol supports refinement of clinical guidelines and the implementation of home-based saliva testing for salivary gland dysfunction.
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