Evidence map›Paper›PMID 41742368›Full record

ArticleSurgical infections2026

Linking Antimicrobial Agent Resistance Profiles to Clinical Outcomes in Pediatric Perforated Appendicitis.

Korry T Wirth, Abigail F Loszko, Matthew M Byrne, Derek S Wakeman, Martin S Pavelka, Timothy M Baran, Nicole A Wilson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgical infections, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Korry T WirthDivision of Pediatric Surgery, Department of Surgery, University of Rochester Medical Center, Rochester, New York, USA.
Abigail F LoszkoDivision of Pediatric Surgery, Department of Surgery, University of Rochester Medical Center, Rochester, New York, USA.
Matthew M ByrneDivision of Pediatric Surgery, Department of Surgery, University of Rochester Medical Center, Rochester, New York, USA.
Derek S WakemanDivision of Pediatric Surgery, Department of Surgery, University of Rochester Medical Center, Rochester, New York, USA.
Martin S PavelkaDepartment of Microbiology and Immunology, University of Rochester, Rochester, New York, USA.
Timothy M BaranDepartment of Biomedical Engineering, University of Rochester, Rochester, New York, USA.
Nicole A WilsonDivision of Pediatric Surgery, Department of Surgery, University of Rochester Medical Center, Rochester, New York, USA.ORCID 0000-0002-0844-1885

Funding

The University of Rochester's Clinical and Translational Science InstituteUL1TR002001 · NCATS · UNIVERSITY OF ROCHESTER · PI WILSON, KAREN M., ZAND, MARTIN S · 2016 to 2024
$34.6M
NCATS NIH HHS UL1 TR002001
6 · The paper itself

Abstract

backgroundComplicated appendicitis remains a leading cause of post-operative morbidity in children, but the relationship between specific microbial resistance profiles and clinical outcomes is poorly defined.

methodsWe conducted a retrospective cohort study of pediatric patients (<18 y) who underwent appendectomy for complicated appendicitis at a tertiary children's hospital (2019-2024). Demographic, operative, and outcome data were abstracted from the National Surgical Quality Improvement Program Pediatric database and electronic health records. Intra-operative cultures were analyzed for bacterial species, gram stain morphology, and antibiotic agent resistance. Hierarchical clustering of weighted resistance scores identified resistance-based microbial groupings. The primary outcome was post-operative organ-space infection (OSI), and secondary outcomes included length of stay (LOS) and 30-day re-admission.

resultsAmong 194 children (median age = 10.2 y; 56.2% male), 26 (13.4%) developed OSI. Culture analysis (n = 176 with samples) demonstrated that polymicrobial infections with ≥3 bacterial species isolated and the presence of

conclusionsChildren with OSI exhibited distinct microbiologic features, including polymicrobial cultures and

Indexed as

Anti-Bacterial AgentsAppendicitisDrug Resistance, BacterialSurgical Wound InfectionAdolescentAppendectomyBacteriaChildChild, PreschoolFemaleHumansLength of StayMaleRetrospective StudiesTreatment OutcomeAnti-Bacterial Agentsantimicrobial agent resistanceappendicitisorgan–space infectionpediatric surgerypost-operative outcomes

Identifiers

PMID41742368
PMCPMC13158973

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.