Evidence map›Paper›PMID 41742359›Full record

Observational studyThe Pediatric infectious disease journal2026

Safety and Efficacy of Intraventricular Antibiotics for Central Nervous System Infections in Children: A Single-center Observational Study.

Mona Almarzooqi, Fionnuala Ryan, Seilesh Kadambari, James Hatcher, Dulanka Silva, Sara Boyd, Orlagh McGarrity, Hanna Schmid

Abstract readObservational Study
In one paragraph

Observational study in The Pediatric infectious disease journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mona AlmarzooqiFrom the Department of Paediatric Infectious Diseases, Great Ormond Street Hospital NHS Foundation Trust.
Fionnuala RyanFrom the Department of Paediatric Infectious Diseases, Great Ormond Street Hospital NHS Foundation Trust.
Seilesh KadambariFrom the Department of Paediatric Infectious Diseases, Great Ormond Street Hospital NHS Foundation Trust.ORCID 0000-0003-3658-7635
James HatcherDepartment of Microbiology, Virology and Infection Control, Great Ormond Street Hospital for Children NHS Foundation Trust.
Dulanka SilvaDepartment of Neurosurgery, Great Ormond Street Hospital NHS Foundation Trust, London.
Sara BoydDepartment of Microbiology, Virology and Infection Control, Great Ormond Street Hospital for Children NHS Foundation Trust.
Orlagh McGarrityDepartment of Pharmacy, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom.
Hanna SchmidFrom the Department of Paediatric Infectious Diseases, Great Ormond Street Hospital NHS Foundation Trust.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intraventricular antibiotics represent a potential adjunct to intravenous antibiotics in central nervous system infections, to achieve adequate drug concentrations in cerebrospinal fluid. In our single-center experience, describing 37 treatment episodes, intraventricular antibiotics mostly targeting shunt-associated central nervous system infections were generally well tolerated and associated with rapid clearance of cerebrospinal fluid. Large randomized controlled trials are needed to better assess treatment efficacy.

Indexed as

Anti-Bacterial AgentsCentral Nervous System InfectionsChildChild, PreschoolFemaleHumansInfantInjections, IntraventricularMaleTreatment OutcomeAnti-Bacterial Agentsexternal ventricular deviceintraventricular antibioticsventriculoperitoneal

Identifiers

PMID41742359
PMCPMC13446907

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.