ReviewJournal of translational medicine2026
Innate immune functions of bitter taste receptors across physiological systems.
Review in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
backgroundBitter taste receptors (TAS2Rs) were initially regarded as sensors for potentially toxic substances, but accumulating evidence indicates that they also play an important role in the regulation of innate immunity. The aim of this study is to summarize the major immunological functions of bitter taste receptors and to clarify their relevance across different physiological systems. MAIN BODY: Current studies suggest that bitter taste receptors contribute to microbial sensing and immune defense in the respiratory tract, maintain microbial homeostasis and antimicrobial activity in the digestive system, and participate in inflammatory regulation and local immune balance in the musculoskeletal and reproductive systems. In addition, they are involved in immune-related processes in the nervous, circulatory, endocrine, and urinary systems.
conclusionsCollectively, these findings indicate that bitter taste receptors act as widely distributed immune-sensing molecules that link environmental stimuli to innate immune responses, providing a broader framework for understanding multisystem immune defense mechanisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.