ArticleBMC pregnancy and childbirth2026
Association between maternal cervical Ureaplasma urealyticum colonization and adverse perinatal outcomes: a prospective multicenter cohort study.
Article in BMC pregnancy and childbirth, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe association between maternal cervical Ureaplasma urealyticum (Uu) colonization and adverse perinatal outcomes remains controversial. This study aimed to investigate the relationship between maternal cervical Uu colonization, Uu load during mid-pregnancy, and perinatal outcomes, with a focus on complications in preterm infants.
methodsThis prospective multicenter cohort study was conducted between July 2021 and January 2024 at four tertiary-level maternity and children’s hospitals in Zhejiang Province, China. Pregnant women with ultrasound-confirmed gestational age of 20+ 0 to 24+ 6 weeks were enrolled, and cervical Uu colonization was assessed by polymerase chain reaction (PCR). Pregnancy outcomes, including spontaneous preterm birth, pregnancy loss, and neonatal complications, were systematically recorded and analyzed.
resultsAmong 452 enrolled participants in this prospective multicenter study, 243 (42.5%) tested positive for Uu colonization. The median Uu DNA load among Uu-positive pregnant women was 1.46 × 105copies/ml. The rate of discontinuation of life-sustaining therapy among preterm infants born at 23–25 weeks of gestation was significantly higher in the Uu-positive group compared to the Uu-negative group (3.7% vs. 0.5%, P = 0.045). Women with high Uu load (≥ 10⁵ copies/mL) had significantly increased rates of spontaneous preterm birth before 32 weeks, spontaneous preterm birth before 28 weeks, premature rupture of membranes (PROM), and neonatal death, compared to those with low or no colonization (P < 0.05). Multivariate analysis identified Uu load ≥ 10⁵ copies/mL as an independent risk factor for preterm birth before 32 weeks of gestation, with an OR of 5.653 (95%CI: 2.032 ~ 15.727).
conclusionsMaternal cervical Uu load ≥10⁵ copies/mL may be associated with increased risk of spontaneous preterm birth before 32 weeks.
trial registrationThe research protocol was registered in the Chinese Clinical Trial Registry (No. ChiCTR2100044524) on 10 March 2021.
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