Evidence map›Paper›PMID 41742046›Full record

ArticleBMC infectious diseases2026

Utility of CBC-derived ratios in the diagnosis and prediction of active tuberculosis in people with rheumatic diseases.

Fengying Wu, Xiaochun Shi, Yuanchun Li, Lantian Xie, Yuchen Liu, Ye Liu, Lifan Zhang, Xiaoqing Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Fengying WuDivision of Infectious Diseases, Department of Internal Medicine, State Key Laboratory of Complex Severe and Rare Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, 100730, China.
Xiaochun ShiDivision of Infectious Diseases, Department of Internal Medicine, State Key Laboratory of Complex Severe and Rare Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, 100730, China.
Yuanchun LiDivision of Infectious Diseases, Department of Internal Medicine, State Key Laboratory of Complex Severe and Rare Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, 100730, China.
Lantian XieDivision of Infectious Diseases, Department of Internal Medicine, State Key Laboratory of Complex Severe and Rare Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, 100730, China.
Yuchen LiuDivision of Infectious Diseases, Department of Internal Medicine, State Key Laboratory of Complex Severe and Rare Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, 100730, China.
Ye LiuDivision of Infectious Diseases, Department of Internal Medicine, State Key Laboratory of Complex Severe and Rare Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, 100730, China.
Lifan ZhangDivision of Infectious Diseases, Department of Internal Medicine, State Key Laboratory of Complex Severe and Rare Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, 100730, China.
Xiaoqing LiuDivision of Infectious Diseases, Department of Internal Medicine, State Key Laboratory of Complex Severe and Rare Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, 100730, China. liuxq@pumch.cn.

Funding

the National High-Level Hospital Clinical Research Funding and the Zhiqian Chen Health Decision Making Fund Project of Peking Union Medical Foundation. 2022-PUMCH-C-013
6 · The paper itself

Abstract

objectiveActive tuberculosis (ATB) largely relied on clinical diagnosis because of the limited sensitivity of microbiologic testing. We assessed whether complete blood cell count (CBC)-derived ratios could assist in ATB diagnosis and risk assessment.

methodsThis study enrolled 305 people with ATB and 171 healthy controls (HC) to evaluate the diagnostic efficiency of CBC-derived ratios for ATB by receiver operating characteristic curves and validated in a multi-center rheumatic disease (RD) cohort, in which a nested case-control study was designed to reveal the relationship between CBC-derived ratios and risk of developing ATB.

resultsPlatelet, monocyte, and neutrophil count increased, but lymphocyte count decreased, thereby, platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and neutrophil-to-lymphocyte ratio (NLR) were elevated significantly in people with ATB compared to HC, the similar tendency was shown between people with post- and pre-the onset ATB. These indices were restored after anti-tuberculosis treatment. Moreover, PLR, MLR, NLR, especially combining monocyte count, PLR, and NLR (area under the curve (AUC) = 0.916, P < 0.001) exhibited good diagnostic efficiency for ATB. Additionally, people with RD concomitant ATB demonstrated a similar tendency of CBC-derived ratios but their diagnostic efficiency for ATB was limited in the RD population. Interestingly, the risk of developing ATB of people with PLR ≥ 130.27 was higher by 23.761-fold than those with PLR < 130.27 in this population within one year.

conclusionCBC-derived ratios have limited standalone diagnostic value in RD populations (AUC = 0.637) but may aid risk stratification. CBC-derived ratios should be considered complementary tools, not replacements, for microbiological tests, particularly in resource-limited settings or to prompt further definitive testing.

Indexed as

Rheumatic DiseasesTuberculosisAdultAgedBlood Cell CountCase-Control StudiesFemaleHumansMaleMiddle AgedROC CurveActive tuberculosisMonocyte-to-lymphocyte ratioNeutrophil-to-lymphocyte ratioPlatelet-to-lymphocyte ratioRheumatic disease

Identifiers

PMID41742046
PMCPMC13041332

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.