Evidence map›Paper›PMID 41741899›Full record

ArticleInflammation2026

Proline-Mediated Inhibition of ATPIF1-mTOR Signaling Alleviates Radiation-Induced Macrophage Polarization and Colon Inflammation.

Lei Chang, Le Zhou, Shan Jiang, Kai Wei, Jie Li, Junhong Zhao, Kavita Shah, Xinzhou Deng, Renhuang Sun, Xiaoyu Zuo and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lei Chang *Department of Urology, Tongji Medical College, Central Hospital of Wuhan, Huazhong University of Science and Technology, Wuhan, 430014, China.
Le Zhou *Department of Clinical Oncology, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Shan Jiang *Department of Clinical Oncology, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Kai Wei *Department of Gastrointestinal Surgery, Tongji Medical College, Central Hospital of Wuhan, Huazhong University of Science and Technology, Wuhan, 430014, China.
Jie LiDepartment of Laboratory Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, Hubei province, China.
Junhong ZhaoCenter for Neurological Disease Research, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, Hubei province, China.
Kavita ShahDepartment of Chemistry and Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN, USA.
Xinzhou DengDepartment of Clinical Oncology, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Renhuang SunDepartment of Clinical Oncology, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Xiaoyu ZuoHubei University of Medicine, Shiyan, 442000, Hubei province, China.
Zhenzhen WangJiangxi University of Traditional Chinese Medicine, Nanchang, 330001, China.
Liting DingDepartment of Rheumatology and Clinical Immunology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, 330001, China.
Zhiguo LuoDepartment of Clinical Oncology, Taihe Hospital, Hubei University of Medicine, Shiyan, China. luozhiguo@hbmu.edu.cn.
Lihua DuanDepartment of Rheumatology and Clinical Immunology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, 330001, China. lh-duan@163.com.
Yutao YanDepartment of Rheumatology and Clinical Immunology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, 330001, China. yanyutao@ncmc.edu.cn.

Funding

National Natural Science Foundation of China 62363028National Natural Science Foundation of China 82371773Natural Science Foundation of Hubei Province of China 2023AFB1007
6 · The paper itself

Abstract

Radiation therapy often triggers inflammatory complications such as radiation colitis, which is driven by persistent M1 macrophage polarization. While metabolic reprogramming is pivotal in macrophage activation, the role of amino acid metabolism-particularly proline-in regulating radiation-induced inflammation remains unexplored. In this study, bone marrow-derived macrophages (BMDMs) and RAW264.7 cells exposed to 4 Gy radiation exhibited robust M1 polarization (increasing from 13.5% in controls to 23.7% in F4/80

Indexed as

ColitisMacrophagesProlineTOR Serine-Threonine KinasesAnimalsCell PolarityMacrophage ActivationMiceRAW 264.7 CellsSignal TransductionmTOR protein, mouseProlineTOR Serine-Threonine KinasesATPIF1MacrophageMTORProlineRadiation colitis

Identifiers

PMID41741899
PMCPMC12960323

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.