ArticleGeroScience2026
Cardiovascular risk factors and vascular neuropathological findings in primary age-related tauopathy versus Alzheimer's disease.
Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Cardiovascular risk factors (CVRFs) are prevalent and modifiable contributors to dementia risk; however, their contributions to vascular pathologies across dementia etiologies has not been examined extensively. This study assessed differences in the prevalence of CVRFs and vascular neuropathologies between people with primary age-related tauopathy (PART) and Alzheimer's disease neuropathology (ADNP), and whether CVRFs associated differentially with vascular co-neuropathologies and antemortem cognitive status between groups. 5144 individuals from the National Alzheimer's Coordinating Center with PART or ADNP were included. The prevalence of CVRFs (hypertension, diabetes, obesity, hypercholesterolemia), and vascular pathologies (cerebral amyloid angiopathy [CAA], cerebrovascular neuropathology [CVNP], arteriolosclerosis, and atherosclerosis) were compared between participants with PART and ADNP. Associations between CVRFs and vascular pathologies were compared between PART and ADNP. Associations between vascular pathologies and Mini Mental Status Examination (MMSE) scores at last visit were compared between PART and ADNP. Diabetes and obesity were more prevalent in individuals with PART compared to ADNP. Individuals with PART had lower prevalence of CAA, arteriolosclerosis, and atherosclerosis. Associations between CVRFs and vascular pathologies differed between PART and ADNP; in PART, diabetes associated with CVNP and obesity associated with arteriolosclerosis, while in ADNP, hypercholesterolemia more strongly associated with CVNP. ADNP associated with lower MMSE scores versus PART. In PART, arteriolosclerosis associated with lower MMSE scores, while in ADNP, CAA and atherosclerosis associated with lower MMSE scores. These findings highlight differences in neuropathological manifestations of CVRFs, and their relationships with antemortem cognitive status, in the presence of PART vs. AD neurodegenerative pathology.
Indexed as
Identifiers
41741895What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.