Evidence map›Paper›PMID 41741809›Full record

SynthesisClinical and experimental nephrology2026

Exercise therapy for kidney transplant recipients: a systematic review and meta-analysis with a focus on exercise type.

Noriyuki Kounoue, Shintaro Ochiai, Masahiko Yazawa, Tadashi Sofue, Naohiko Fujii, Masakazu Saitoh, Ichiei Narita, Kunihiro Yamagata, Junichi Hoshino, Hideyo Oguchi

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Clinical and experimental nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Noriyuki Kounoue *Department of Nephrology, Toho University Faculty of Medicine, Omorinishi 6-11-1, Ota-Ku, Tokyo, 143-8541, Japan.
Shintaro Ochiai *Department of Nephrology, Toho University Faculty of Medicine, Omorinishi 6-11-1, Ota-Ku, Tokyo, 143-8541, Japan.
Masahiko YazawaDepartment of Internal Medicine, Yokohama General Hospital, Yokohama, Japan.
Tadashi SofueDepartment of Cardiorenal and Cerebrovascular Medicine, Kagawa University, Kagawa, Japan.
Naohiko FujiiDepartment of Nephrology, Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Japan.
Masakazu SaitohDepartment of Physical Therapy, Faculty of Health Science, Juntendo University, Tokyo, Japan.
Ichiei NaritaNiigata Institute for Health and Sports Medicine, Niigata Sports Association, Niigata, Japan.
Kunihiro YamagataDepartment of Nephrology, Faculty of Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba and Division of Preventive and Sports Nephrology, University of Tsukuba, Ibaraki, Japan.
Junichi HoshinoDepartment of Nephrology, Tokyo Women's Medical University, Tokyo, Japan.
Hideyo OguchiDepartment of Nephrology, Toho University Faculty of Medicine, Omorinishi 6-11-1, Ota-Ku, Tokyo, 143-8541, Japan. hideyo.oguchi@med.toho-u.ac.jp.ORCID http://orcid.org/0000-0002-7462-3564

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExercise therapy is important for exercise tolerance, for the prevention of frailty or sarcopenia, and to improve quality of life (QOL). Previous studies, including systematic reviews, have shown the efficacy of exercise therapy for kidney transplant recipients (KTRs), but the optimal types of exercise remain unclear. Therefore, we aimed to synthesize the published evidence and compare the efficacy of types of exercise.

methodsWe systematically searched for randomized controlled trials of the efficacy of exercise therapy in KTRs on PubMed and Ichushi, then performed a meta-analysis. Exercise was categorized as aerobic training (AT), resistance training (RT), or AT + RT. The risk of bias was assessed using ROB2 and the certainty of the evidence was evaluated using the GRADE approach.

resultsTwenty-five studies were included in the study and 18 in the meta-analysis. Exercise was associated with significant improvements in QOL (SF-36 physical functioning score), cardiorespiratory function (VO

conclusionExercise therapy improved the QOL, cardiorespiratory function, physical function, and triglyceride concentration of KTRs. The AT + RT combination may be the most effective exercise therapy for such patients.

Indexed as

Exercise TherapyKidney TransplantationExercise ToleranceHumansQuality of LifeResistance TrainingTreatment OutcomeExercise therapyExercise typeKidney transplantation

Identifiers

PMID41741809

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.