Evidence map›Paper›PMID 41741759›Full record

ArticleCommunications biology2026

Microglial serine racemase knockout alleviates Alzheimer-like neuropathology and behavioral deficit via lactylation-mediated anti-inflammation.

Jing Zhou, Yuanhong Yang, Shuyi Liu, Juan Chen, Hongji Liao, Wenjing Liang, Zhiwen Zhang, Yan Wang, Yimei Liu, He Zhang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jing Zhou *State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Yuanhong Yang *State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Shuyi Liu *State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Juan ChenState Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Hongji LiaoState Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Wenjing LiangState Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Zhiwen ZhangState Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Yan WangState Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China.ORCID http://orcid.org/0000-0003-4443-8672
Yimei LiuState Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
He ZhangZhejiang Provincial Key Lab for Subtropical Water Environment and Marine Biological Resources Protection, College of Life and Environmental Science, Wenzhou University, Wenzhou, China.
Haiyan JiangState Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Wenchu LinThe Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen & Longgang District People's Hospital of Shenzhen, Shenzhen, China.
Jia QuState Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Steven W BargerDepartment of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Shengzhou WuState Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China. wszlab@wmu.edu.cn.ORCID http://orcid.org/0000-0003-1154-2369

Funding

Eye Hospital Wenzhou Medical University J02-20190204
6 · The paper itself

Abstract

Serine racemase (SR) dysregulation associates with brain aging and Alzheimer's disease (AD), as both a deficiency and an excess of D-serine can impact synaptic neurotransmission and the integrity of synapses. Neuronal SR decreases with aging, while glial SR is upregulated in AD. However, the role of SR in microglia involved in AD remains elusive. Here, Srr knockdown/knockout in microglia enhanced whereas overexpression of SR inhibited phagocytosis. Lipopolysaccharide-treated Srr

Indexed as

Alzheimer DiseaseMicrogliaRacemases and EpimerasesAnimalsDisease Models, AnimalFemaleMaleMiceMice, KnockoutPhagocytosisSerine RacemaseRacemases and EpimerasesSerine Racemase

Identifiers

PMID41741759
PMCPMC13056901

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.