ArticleEye (London, England)2026
AI-assisted analysis of early fluid dynamics following aflibercept 8 mg in treatment-naïve neovascular AMD.
Article in Eye (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo evaluate early morphological changes following intravitreal aflibercept 8 mg in treatment-naïve neovascular age-related macular degeneration (nAMD) using artificial intelligence (AI)-assisted optical coherence tomography (OCT) segmentation.
methodsThirty eyes with treatment-naïve subfoveal nAMD received three monthly aflibercept 8 mg injections. OCT scans were obtained at baseline and days 1, 7, 14, 30, 60, and 90. AI-based segmentation software (Fluid Monitor, RetInSight GmbH) quantified intraretinal fluid (IRF), subretinal fluid (SRF), and pigment epithelial detachment (PED) volumes in the central 6-mm area. Morphologic changes were correlated with best-corrected visual acuity (BCVA).
resultsIRF, SRF, and PED showed distinct reduction patterns. In eyes with IRF (n = 22), mean volume decreased by 65% at day 1, 94% at day 14, and 96% at day 90 (p < 0.05). Among eyes with SRF (n = 28), SRF volume decreased by 18%, 84%, and 99% at days 1, 14, and 90, respectively (p ≤ 0.002). PED volume declined more gradually among affected eyes (n = 23), with mean reductions of 7% at day 1, 34% by day 14, and 53% by day 90 (p ≤ 0.023). BCVA improved from 51.8 ± 14.4 to 62.6 ± 14.4 ETDRS letters by day 90 (mean gain + 10.8; p < 0.001). Multivariate regression identified a significant association between IRF reduction at day 14 and BCVA gain at day 90 (β = -0.018, p = 0.036).
conclusionsAflibercept 8 mg induced rapid, compartment-specific morphologic responses in treatment-naïve nAMD, with early IRF resolution and significant BCVA improvement. AI-assisted analysis provided detailed pharmacodynamic insights and may support individualised treatment strategies during the loading phase.
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