ArticleEye (London, England)2026
Paediatric uveal melanoma in Ireland 2010 - 2024: incidence, clinical features, management, and outcomes.
Article in Eye (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUveal melanoma is predominantly an adult malignancy, with Ireland reporting one of the highest incidence rates at 9.5 cases per million adults annually. Paediatric uveal melanoma is extremely rare, accounting for fewer than 1% to 2% of all uveal melanoma cases in published series.
methodsThis retrospective study included all patients under 18 years of age diagnosed with uveal melanoma in Ireland between 2010 and 2024. Data were collected from medical records and included demographics, tumour location and dimensions, histopathology or cytology (where available), presence of metastasis, treatment modality, baseline and final visual acuity, intraocular pressure, and survival outcomes.
resultsSix Caucasian patients (five male, one female), aged 6 to 17 years, were identified. Tumour locations included five choroidal and one ciliochoroidal melanoma. Treatment modalities included enucleation (n = 2), plaque brachytherapy (two Ruthenium-106, one Iodine-125), and proton beam radiotherapy (n = 1). Histopathological analysis was available in two cases, revealing one mixed cell type and one spindle B melanoma. Fine needle aspiration biopsy was performed in two patients. Mean follow-up was 30 months (median 24; range 12-178). All cases remained metastasis-free at last follow-up.
conclusionsThis national case series highlights the rarity and clinical relevance of paediatric uveal melanoma. Outcomes have been favourable, but recent case clustering supports the need for international comparative data collection. Early diagnosis and appropriate treatment help preserve vision and reduce morbidity. Molecular profiling, where possible, may guide metastatic risk assessment. Further studies are needed to confirm international incidence trends.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.