Evidence map›Paper›PMID 41741699›Full record

ArticleEye (London, England)2026

Clinical significance of serum IgE levels in IgG4-related ophthalmic disease: a single-centre study.

Tingting Ren, Jing Li, Rui Liu, Nan Wang, Qihan Guo, Liangyuan Xu, Haihan Yan, Yufei Zhang, Jianmin Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Eye (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tingting Ren *Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Jing Li *Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Rui LiuBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Nan WangBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Qihan GuoBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Liangyuan XuBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Haihan YanBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Yufei ZhangBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Jianmin MaBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China. jmma@sina.com.ORCID http://orcid.org/0000-0001-8667-8645

Funding

Beijing Nova Program 20220484218Natural Science Foundation of Beijing Municipality (Beijing Natural Science Foundation) 7222025
6 · The paper itself

Abstract

objectiveTo explore the role of serum IgE in IgG4-related ophthalmic disease (IgG4-ROD) by comparing clinical features and prognosis of patients with elevated and normal serum IgE levels.

methodsThis single-centre retrospective study included 54 IgG4-ROD patients diagnosed by histopathology from March 2022 to March 2024. Clinical features of the IgE+ group (serum IgE levels >165 IU/ml) and the IgE- group (serum IgE levels ≤ 165 IU/ml) were compared, and 50 patients were followed for at least 6 months to assess the prognosis. Statistical analyses included t tests, Mann-Whitney U, chi-square tests, Spearman correlation, Kaplan-Meier survival curves, and Cox regression.

resultsAmong the 54 patients, both the IgE+ (n = 22) and IgE- groups (n = 32) were predominantly middle-aged women. Extraocular muscle involvement was more common in the IgE- group (P = 0.033), whereas bilateral ocular (P = 0.040) and sinus involvement (P = 0.046) were more frequent in the IgE+ group. Significant intergroup differences were observed in serum IgG4 (P = 0.004), C1q (P = 0.021), IL-10 levels (P = 0.030), IgG4/IgG (P = 0.022), and IgE/IgG4 ratios (P = 0.018). Serum IgE correlated positively with IgG4, IL-6, IL-10, and IL-12p70, and negatively with C1q and IgM (P < 0.05). The IgE+ group had a higher relapse risk (P = 0.038). Cox regression analysis identified serum IgE as an independent risk factor for relapse (P = 0.022).

conclusionElevated serum IgE in IgG4-ROD is associated with more severe disease and higher relapse risk, highlighting its potential as a prognostic marker.

Indexed as

Immunoglobulin EImmunoglobulin GImmunoglobulin G4-Related DiseaseAdultAgedBiomarkersFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesBiomarkersImmunoglobulin EImmunoglobulin G

Identifiers

PMID41741699
PMCPMC13161202

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.