ArticleNature2026
CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.
Abstract read
In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- CRISPR Technologies in Type 2 Diabetes: From Mechanistic Insights to Therapeutic Discovery.International journal of molecular sciences · 2026Review
- The accessory protein ORF3a hijacks the CLCC1 chloride channel to disrupt ER homeostasis in betacoronavirus pathogenesis.Cell discovery · 2026Article
- Mechanisms underlying propagation of ferroptotic cell death.Nature cell biology · 2026Review
- Article
- Article
- ER protein CLCC1 promotes nuclear envelope fusion in herpesviral and host processes.Nature communications · 2025Article
- CHP1 promotes lipid droplet growth and regulates the localization of key enzymes for triacylglycerol synthesis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Plasma membrane accessible cholesterol is regulated by ACC1 and lipid droplets.bioRxiv : the preprint server for biology · 2025Article
- Zebrafish are resilient to the loss of major diacylglycerol acyltransferase enzymes.The Journal of biological chemistry · 2024Article
- TorsinA is essential for neuronal nuclear pore complex localization and maturation.Nature cell biology · 2024Article
Corrections and comments
- Update of
Authors and funding
26 authors.
Alyssa J Mathiowetz *Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Emily S Meymand *Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Güneş ParlakgülDepartment of Metabolic Biology and Nutrition, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0001-9365-7287
Niek van HiltenCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0003-1204-2489
Emily F TorresDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0001-9074-8909
Leonardo L ArticoDepartment of Metabolic Biology and Nutrition, University of California, Berkeley, Berkeley, CA, USA.
Kirandeep K DeolDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Mike LangeDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0002-4728-9927
Stephany P PangDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Cody E DoubravskyDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0009-0004-6473-7092
Melissa A RobertsDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Danielle M JorgensElectron Microscope Laboratory, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0002-7143-0118
Reena ZalpuriElectron Microscope Laboratory, University of California, Berkeley, Berkeley, CA, USA.
Misun KangElectron Microscope Laboratory, University of California, Berkeley, Berkeley, CA, USA.
Casadora BooneDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Brian W ParksDepartment of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Yaohuan ZhangDepartment of Metabolic Biology and Nutrition, University of California, Berkeley, Berkeley, CA, USA.
David W MorgensDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Emily Tso NewmanMerck & Co., South San Francisco, CA, USA.
Yingjiang ZhouMerck & Co., South San Francisco, CA, USA.ORCID 0000-0002-8910-0272
Saswata TalukdarMerck & Co., South San Francisco, CA, USA.
Michael GrabeCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0003-3509-5997
Gregory KuDepartment of Medicine, Division of Endocrinology, University of California, San Francisco, San Francisco, CA, USA.
Tim P LevineUniversity College London Institute of Ophthalmology, London, UK.ORCID 0000-0002-7231-0775
Ana Paula ArrudaDepartment of Metabolic Biology and Nutrition, University of California, Berkeley, Berkeley, CA, USA. aarruda@berkeley.edu.ORCID 0000-0001-6179-2687
James A OlzmannDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA. olzmann@berkeley.edu.ORCID 0000-0001-7751-8316
Funding
UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6MMolecular Mechanisms of Lipid Droplet BiogenesisR01GM112948 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI OLZMANN, JAMES A · 2015 to 2024
$3.1MRegulation of Cholesterol Metabolism by Sestrin1R01HL147097 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI PARKS, BRIAN WESLEY · 2019 to 2023
$1.9MPREP @ UC BerkeleyR25GM140276 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI GIAN GARRIGA, Julia Schaletzky · 2022 to 2026
$1.9MICP-QQQS10OD030258 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI JORGENS, DANIELLE MARY · 2021 to 2021
$1.6MLipid droplet regulation and proteome dynamicsR01DK128099 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI OLZMANN, JAMES A · 2021 to 2025
$1.6MIon permeation, lipid flipping, and membrane remodeling by TMEM16 proteinsR01GM137109 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRABE, MICHAEL · 2021 to 2024
$1.4MThe role of hepatic Endoplasmic Reticulum architecture in metabolic homeostasis and diseaseR01DK140367 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI Ana Paula Arruda · 2024 to 2026
$1.2MElucidating the relationship between lipid droplets, oxidative lipid damage, and ferroptosisR01CA305423 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI JAMES A OLZMANN · 2025 to 2026
$714kAcquisition of an Orbitrap MSS10OD010645 · OD · UNIVERSITY OF MASSACHUSETTS AMHERST · PI EYLES, STEPHEN J. · 2013 to 2013
$600kNCI NIH HHS R01 CA305423NHLBI NIH HHS R01 HL147097NIDDK NIH HHS P30 DK098722NIDDK NIH HHS R01 DK128099NIDDK NIH HHS R01 DK140367NIGMS NIH HHS R01 GM112948NIGMS NIH HHS R01 GM137109NIGMS NIH HHS R25 GM140276NIH HHS S10 OD010645NIH HHS S10 OD030258
Abstract
Imbalances in lipid storage and secretion lead to hepatic steatosis, the accumulation of lipid droplets in hepatocytes
Indexed as
Lipid MetabolismLiverNuclear PoreAnimalsCRISPR-Cas SystemsFatty LiverFemaleHepatocytesHumansLipid DropletsLipoproteinsMaleMembrane FusionMiceMice, KnockoutMolecular Dynamics SimulationLipoproteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.