Evidence map›Paper›PMID 41741633›Full record

ArticleThe EMBO journal2026

Structural determinants for GPCR-mediated inhibition of TASK K2P channels by diacylglycerol and its dysfunction in disease.

Thibault R H Jouen-Tachoire, Peter Proks, David Seiferth, Kate Crowther, Philip C Biggin, Thomas Baukrowitz, Marcus Schewe, Stephen J Tucker

Abstract read
In one paragraph

Article in The EMBO journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Thibault R H Jouen-Tachoire *Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-5867-994X
Peter Proks *Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-6097-3646
David SeiferthDepartment of Biochemistry, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-4250-558X
Kate CrowtherKavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-6384-8637
Philip C BigginDepartment of Biochemistry, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-5100-8836
Thomas BaukrowitzInstitute of Physiology, Kiel University, Kiel, Germany.ORCID http://orcid.org/0000-0003-4562-0505
Marcus ScheweInstitute of Physiology, Kiel University, Kiel, Germany. m.schewe@physiologie.uni-kiel.de.ORCID http://orcid.org/0000-0002-6192-5651
Stephen J TuckerKavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK. stephen.tucker@physics.ox.ac.uk.ORCID http://orcid.org/0000-0001-8996-2000

Funding

Deutsche Forschungsgemeinschaft (DFG) BA 1793/6-2Deutsche Forschungsgemeinschaft (DFG) SCHE 2112/1-2Leibniz Collaborative Excellence Programme K622/2024UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BB/M011224/1UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BB/S001247/1UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BB/S008608/1UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BB/T002018/1UKRI | Medical Research Council (MRC) MR/W017741/1Wellcome TrustWellcome Trust (WT) 102161/B/13/ZWellcome Trust (WT) WT084655MA
6 · The paper itself

Abstract

Two-Pore Domain K+ (K2P) channels are crucial determinants of the resting membrane potential and of cellular electrical excitability in many different cell types. TASK-1 and TASK-3 K2P channel activity is also coupled to GPCR signalling pathways via Gαq and their subsequent inhibition is via direct interaction with diacylglycerol (DAG) generated from phosphatidylinositol-4,5-bisphosphate (PIP

Indexed as

DiglyceridesNerve Tissue ProteinsPotassium Channels, Tandem Pore DomainReceptors, G-Protein-CoupledAnimalsHEK293 CellsHumansPhosphatidylinositol 4,5-DiphosphateSignal TransductionTwo-Pore ChannelsDiglyceridesNerve Tissue ProteinsPhosphatidylinositol 4,5-DiphosphatePotassium Channels, Tandem Pore Domainpotassium channel subfamily K member 3Receptors, G-Protein-CoupledTwo-Pore ChannelsChannelopathyDiacylglycerolGPCR/K2P ChannelKCNK3

Identifiers

PMID41741633
PMCPMC13043741

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.