Evidence map›Paper›PMID 41741497›Full record

ArticleScientific data2026

SexTumorDB: a comprehensive resource of sex-dependent tumor landscape at single-cell resolution.

Ruya Sun, Qiqi Deng, Di Wang

Abstract readDataset
In one paragraph

Article in Scientific data, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ruya Sun *Department of Orthopaedic Surgery of Sir Run Run Shaw Hospital, and Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, 310058, China. sunruya@zju.edu.cn.ORCID http://orcid.org/0000-0002-1867-6776
Qiqi Deng *Department of Orthopaedic Surgery of Sir Run Run Shaw Hospital, and Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Di WangDepartment of Orthopaedic Surgery of Sir Run Run Shaw Hospital, and Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, 310058, China. diwang@zju.edu.cn.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82025017
6 · The paper itself

Abstract

Sex is one of the most fundamental biological variables, with a profound impact on tumor incidence, mortality, treatment response and prognosis, making it a critical consideration for precision oncology. Despite its well-established role in tumors, sex bias is often overlooked in both basic research and clinical practice. Our understanding of sex disparities in tumors, especially in non-reproductive tumors and non-malignant components, remains limited, necessitating a comprehensive investigation of sexual dimorphism in cancer. To address this gap, we developed the SexTumorDB database, an integrated resource containing RNA sequencing profiles of non-reproductive tumors at single-cell resolution. SexTumorDB covers 13 cancer types with the highest incidence in either males or females, encompassing 2,014,043 cells from 532 samples, including 319 male and 213 female samples. The SexTumorDB datasets were rigorously curated, processed, and standardized. By making this resource publicly available through online repositories and web applications, we aim to advance the understanding of sex disparities in the tumor microenvironments (TMEs) and foster the development of sex-specific anticancer treatment strategies in the future.

Indexed as

NeoplasmsSex CharacteristicsFemaleHumansMaleSequence Analysis, RNASingle-Cell AnalysisTumor Microenvironment

Identifiers

PMID41741497
PMCPMC13046873

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.