Evidence map›Paper›PMID 41741475›Full record

ArticleNature communications2026

Idiotype-specific CD4

Ramakrishna Prabhu Gopalakrishnan, Jerrold M Ward, Victor Greiff, Ranveig Braathen, Xian Hu, Livia Bajelan, Khang Lê Quý, Ludvig Munthe, Peter Csaba Huszthy, Bjarne Bogen

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ramakrishna Prabhu GopalakrishnanDepartment of Immunology and Transfusion Medicine, Division of Laboratory Medicine, Oslo University Hospital, Oslo, Norway. r.p.gopalakrishnan@medisin.uio.no.ORCID http://orcid.org/0009-0007-0590-2723
Jerrold M WardNational Cancer Institute, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-6350-8982
Victor GreiffDepartment of Immunology and Transfusion Medicine, Division of Laboratory Medicine, Oslo University Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0003-2622-5032
Ranveig BraathenDepartment of Immunology and Transfusion Medicine, Division of Laboratory Medicine, Oslo University Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0003-0451-5936
Xian HuCenter for Cancer Cell Reprogramming, Faculty of Medicine, University of Oslo, Oslo, Norway.
Livia BajelanDepartment of Immunology and Transfusion Medicine, Division of Laboratory Medicine, Oslo University Hospital, Oslo, Norway.
Khang Lê QuýDepartment of Immunology and Transfusion Medicine, Division of Laboratory Medicine, Oslo University Hospital, Oslo, Norway.
Ludvig MuntheDepartment of Immunology and Transfusion Medicine, Division of Laboratory Medicine, Oslo University Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0002-0344-3654
Peter Csaba HuszthyDepartment of Immunology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0003-0184-8989
Bjarne BogenDepartment of Immunology and Transfusion Medicine, Division of Laboratory Medicine, Oslo University Hospital, Oslo, Norway. bjarne.bogen@medisin.uio.no.ORCID http://orcid.org/0000-0001-5387-7461

Funding

Ministry of Health and Care Services | Helse Sør-Øst RHF (Southern and Eastern Norway Regional Health Authority) 39921Norges Forskningsråd (Research Council of Norway) 143073
6 · The paper itself

Abstract

Autoimmunity increases the risk of developing B lymphoma in humans; however, the molecular mechanism(s) underlying this link remain(s) unexplained. Here, we develop a mouse model to dissect the contribution of Id-driven T-B collaboration and show that chronic interaction between B cells and CD4

Indexed as

AutoimmunityB-LymphocytesCD4-Positive T-LymphocytesImmunoglobulin IdiotypesLymphoma, B-CellAnimalsAutoantibodiesAutoantigensGerminal CenterMiceMice, Inbred C57BLReceptors, Antigen, B-CellAutoantibodiesAutoantigensImmunoglobulin IdiotypesReceptors, Antigen, B-Cell

Identifiers

PMID41741475
PMCPMC13057116

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.