ArticleNPJ Parkinson's disease2026
Chronic adaptive deep brain stimulation in Parkinson's disease: ADAPT-START findings and programming principles.
Article in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- The Place of Adaptive Deep Brain Stimulation in Parkinson's Disease: Spatial before Temporal Optimization.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Activity-dependent adaptive deep brain stimulation improves gait in Parkinson's disease.Nature medicine · 2026Article
- Electrographic cue-reactivity co-localizes with accumbens deep brain stimulation in a case of opioid use disorder.Nature communications · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Deep brain stimulation (DBS) is established for Parkinson's disease (PD), but conventional DBS (cDBS) may yield suboptimal symptom control and side effects, particularly on gait. Adaptive DBS (aDBS), adjusting stimulation to subthalamic beta activity, may offer superior outcomes, though programming remains incompletely defined. Between January and April 2025, we offered dual threshold aDBS to 20 consecutive PD patients with chronic cDBS and a Percept neurostimulator. Nine were eligible; exclusions were due to signal artifacts, absence of a distinct beta peak, or stimulation settings incompatible with aDBS. By July 2025, five remained on chronic aDBS, one reverted to cDBS by preference, and three were still in optimization. In this manuscript, we outline our aDBS programming principles and preliminary clinical efficacy. On unblinded MDS-UPDRS III, aDBS yielded a ~35% greater motor improvement than cDBS, with gait showing the most consistent benefits. Dual threshold aDBS appears clinically advantageous, though current technical and programming constraints may limit widespread adoption.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.