Evidence map›Paper›PMID 41741455›Full record

ArticleNature communications2026

Multi-modal skin atlas identifies a multicellular immune-stromal community associated with disrupted cornification and specific T cell expansion in atopic dermatitis.

Evgenij Fiskin, Gökcen Eraslan, Maria B Alora-Palli, Tanvi Jain, Juan Manuel Leyva-Castillo, Sean Kim, Heather Choe, Caleb A Lareau, Helena Lau, Emily P Finan and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Prenatal PMNature communications · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Hidden immune memory niches in inflammatory skin diseases.bioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors.

Evgenij Fiskin *Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Gökcen Eraslan *Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-9579-2909
Maria B Alora-Palli *Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Tanvi Jain *Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Juan Manuel Leyva-CastilloDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7394-4457
Sean KimCenter for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Heather ChoeCenter for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Caleb A LareauDepartments of Pathology, Stanford University, Stanford, CA, USA.
Helena LauCenter for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Emily P FinanKlarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Isabella Teixeira-SoldanoKlarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Brenna LaBereDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Anne ChuDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Brian WoodsDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Janet ChouDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Michal SlyperKlarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Julia WaldmanKlarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-0584-5833
Sabina IslamDivision of Rheumatology, Allergy and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Lynda SchneiderDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Wanda PhipatanakulDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Craig PlattDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1901-4563
Orit Rozenblatt-RosenKlarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-6313-3570
Toni M DeloreyKlarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-6614-3803
Orr AshenbergKlarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Jacques DeguineKlarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-9218-3040
Gideon P SmithDepartment of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Raif S GehaDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. raif.geha@childrens.harvard.edu.
Aviv RegevKlarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA. aviv.regev.sc@gmail.com.ORCID http://orcid.org/0000-0003-3293-3158
Ramnik J XavierKlarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA. xavier@molbio.mgh.harvard.edu.ORCID http://orcid.org/0000-0002-5630-5167

Funding

U.S. Department of Health & Human Services | National Institutes of Health (NIH) DK114784
6 · The paper itself

Abstract

In atopic dermatitis (AD), skin barrier and immune dysfunction result in chronic tissue inflammation, yet our understanding of the tissue ecosystem remains incomplete. Here, we generate a multi-modal census of 280,518 cells from whole skin tissue samples from 17 adults, including 11 AD patients, integrating it with 430,186 cell profiles from four previous studies into a comprehensive human skin cell atlas. Reconstruction of keratinocyte differentiation revealed disrupted cornification in AD associated with signals from an immune and stromal multicellular community - comprising MMP12

Indexed as

Dermatitis, AtopicSkinT-LymphocytesAdultCell DifferentiationDendritic CellsFemaleFibroblastsHumansKeratinocytesKiller Cells, NaturalStromal Cells

Identifiers

PMID41741455
PMCPMC13057205

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.