Evidence map›Paper›PMID 41741452›Full record

ArticleNature communications2026

Spatiotemporally controlled restoration of GAS6 signaling via mRNA therapy promotes scarless healing in preclinical models.

Yan He, Kai Ye, Yufan Zhang, Zhengtai Chen, Hanxiao Sun, Guangying Cui, Parnia Ghanad, Zhengwei Mao, Huang Yang, Zhigang Ren and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yan He *Department of Plastic Surgery, The Second Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, China.
Kai Ye *Department of Plastic Surgery, The Second Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, China.
Yufan Zhang *Department of Plastic Surgery, The Second Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, China.
Zhengtai ChenDepartment of Plastic Surgery, The Second Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, China.
Hanxiao SunDepartment of Plastic Surgery, The Second Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, China.
Guangying CuiState Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Parnia GhanadDepartment of Plastic Surgery, The Second Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, China.ORCID http://orcid.org/0009-0003-8234-368X
Zhengwei MaoMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, Zhejiang, China.ORCID http://orcid.org/0000-0001-7990-2856
Huang YangMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, Zhejiang, China. yanghuang0803@zju.edu.cn.
Zhigang RenState Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. fccrenzg@zzu.edu.cn.ORCID http://orcid.org/0000-0003-0798-3444
Chenggang YiDepartment of Plastic Surgery, The Second Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, China. yichg@zju.edu.cn.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82272296
6 · The paper itself

Abstract

Deep cutaneous injuries in adult mammals often lead to fibrotic scarring, a process exacerbated by inflammatory fibroblasts that amplify immune recruitment. Early modulation of immune-fibroblast crosstalk represents a promising therapeutic strategy. Here we show that GAS6 is a key regulator of this interaction and can be therapeutically targeted using a spatiotemporally controlled lipid nanoparticle (LNP)-mRNA hydrogel platform. We engineer LNP-GAS6 mRNA to enhance macrophage efferocytosis and suppress inflammatory fibroblasts, then encapsulate it in a thermosensitive hydrogel for localized delivery. In murine, rabbit ear, and Bama minipig wound models, this treatment significantly accelerates wound closure and reduces fibrotic scarring. These results demonstrate that restoring GAS6 signaling via mRNA-based delivery promotes scarless healing and offers an effective therapeutic approach for fibrotic skin disorders.

Indexed as

CicatrixIntercellular Signaling Peptides and ProteinsRNA, MessengerWound HealingAnimalsDisease Models, AnimalEfferocytosisFibroblastsGrowth Arrest-Specific Protein 6HumansHydrogelsLiposomesMacrophagesMiceMice, Inbred C57BLNanoparticlesGrowth Arrest-Specific Protein 6HydrogelsIntercellular Signaling Peptides and ProteinsLipid NanoparticlesLiposomesRNA, Messenger

Identifiers

PMID41741452
PMCPMC13046968

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.