ArticleCell death & disease2026
Colony-stimulating factor 1 receptor inhibition is neuroprotective to photoreceptors in retinal detachment.
Sara Pastor-Puente, Rebecca Jung, Lucia Gonzalez-Buendia, Eleftherios I Paschalis, Demetrios G Vavvas, Andrius Kazlauskas, Daniel E Maidana
Abstract read
In one paragraphArticle in Cell death & disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
7 authors.
Sara Pastor-PuenteDepartment of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois Chicago, Chicago, IL, USA.
Rebecca JungDepartment of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois Chicago, Chicago, IL, USA.
Lucia Gonzalez-BuendiaRetina Service, Angiogenesis Lab, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA.
Eleftherios I PaschalisRetina Service, Angiogenesis Lab, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA.
Andrius KazlauskasDepartment of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois Chicago, Chicago, IL, USA.
Funding
P30 Core Grant for Vision ResearchP30EY014104 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Janey L Wiggs · 2002 to 2026
$15.1MTranslational Core for Therapeutic and Diagnostic DevelopmentP30EY001792 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SHUKLA, DEEPAK · 1985 to 2025
$14.8MUIC K12 Independent Clinical Vision Scientist Development ProgramK12EY021475 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ALI R DJALILIAN, CHARLOTTE E JOSLIN · 2011 to 2026
$6.7MDefining the Role of Retinal Microglia and Infiltrating Monocytes on Photoreceptor Cell Death in Retinal DetachmentK08EY034935 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Daniel Enrique E. Maidana · 2023 to 2026
$850kNecroptosis and Neuroprotection in AMDR21EY023079 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI VAVVAS, DEMETRIOS · 2013 to 2014
$404kBayer GOAP Ophthalmology AwardNEI NIH HHS K08 EY034935Novartis | Alcon | Alcon Research Institute (ARI) Young Investigator AwardResearch to Prevent Blindness (RPB) Career Development AwardResearch to Prevent Blindness (RPB) Core GrantResearch to Prevent Blindness (RPB) Physician-Scientist AwardU.S. Department of Health & Human Services | National Institutes of Health (NIH) K08EY034935U.S. Department of Health & Human Services | National Institutes of Health (NIH) K12EY021475U.S. Department of Health & Human Services | National Institutes of Health (NIH) P30EY001792U.S. Department of Health & Human Services | National Institutes of Health (NIH) P30EY014104U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01EY02536201U.S. Department of Health & Human Services | National Institutes of Health (NIH) R21EY023079
6 · The paper itselfAbstract
Retinal detachment (RD) triggers a neuroinflammatory response aimed at clearing damaged photoreceptors (PR) and limiting injury. However, this response can unintentionally worsen retinal neurodegeneration. Retinal microglia (MG) and infiltrating monocytes (Mø) play key roles in this process and are regulated by the colony-stimulating factor 1 receptor (CSF1R). Targeting the CSF1R has been proposed as a potential strategy to modulate neuroinflammation. Using PLX5622, a selective CSF1R inhibitor, we examined the local and systemic immune effects in RD in a novel experimental model with specific MG and Mø labeling. We found that PLX5622 depletes and alters the function of MG and Mø subtypes, modulates myeloid cell infiltration into the retina, and confers neuroprotection to PRs in both acute and chronic phases of RD. These findings highlight that CSF1R inhibition could create a therapeutic window to mitigate early inflammatory damage. Targeting CSF1R may represent a promising therapeutic strategy for neuroprotection in RD.
Indexed as
NeuroprotectionNeuroprotective AgentsPhotoreceptor Cells, VertebrateReceptors, Granulocyte-Macrophage Colony-Stimulating FactorRetinal DetachmentAnimalsMiceMice, Inbred C57BLMicrogliaMonocytesOrganic ChemicalsCsf1r protein, mouseNeuroprotective AgentsOrganic ChemicalsPLX5622Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
Identifiers
PMID41741437
PMCPMC13003037
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390