Evidence map›Paper›PMID 41741431›Full record

ArticleNature communications2026

A ketogenic diet enhances aerobic exercise adaptation and promotes muscle mitochondrial remodeling in hyperglycemic male mice.

Pattarawan Pattamaprapanont, Roberto C Nava, Rea Grover, Mia Formato, Eileen M Cooney, Ana Paula Pinto, Ana B Alves-Wagner, Anamica Das, Yuntian Guan, Meghana Annambhotla and 3 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Pattarawan PattamaprapanontFralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA, USA.ORCID 0000-0001-5611-1146
Roberto C NavaResearch Division, Joslin Diabetes Center, Boston, MA, USA.
Rea GroverFralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA, USA.
Mia FormatoResearch Division, Joslin Diabetes Center, Boston, MA, USA.
Eileen M CooneyResearch Division, Joslin Diabetes Center, Boston, MA, USA.
Ana Paula PintoResearch Division, Joslin Diabetes Center, Boston, MA, USA.ORCID 0000-0002-9139-6746
Ana B Alves-WagnerResearch Division, Joslin Diabetes Center, Boston, MA, USA.
Anamica DasResearch Division, Joslin Diabetes Center, Boston, MA, USA.
Yuntian GuanResearch Division, Joslin Diabetes Center, Boston, MA, USA.
Meghana AnnambhotlaFralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA, USA.
Saanvi AcharyaFralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA, USA.
Donato A RivasFralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA, USA.
Sarah J LessardFralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA, USA. sarahlessard@vtc.vt.edu.ORCID 0000-0003-4693-3191

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI JEAN E. SCHAFFER · 1986 to 2026
$50.5M
TRAINING IN DIABETES AND METABOLISMT32DK007260 · NIDDK · JOSLIN DIABETES CENTER · PI LAURIE J GOODYEAR · 1986 to 2026
$13.6M
Mechanisms for Impaired Adaptation to Aerobic Exercise with Metabolic DiseaseR01DK124258 · NIDDK · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Sarah Lessard · 2020 to 2026
$3.3M
Gut microbial fermentation products of muscle-derived lactate as mediators of exercise and metabolismR01DK129850 · NIDDK · JOSLIN DIABETES CENTER · PI Aleksandar David Kostic, Sarah Lessard · 2022 to 2026
$3.0M
American Diabetes Association (ADA) #1-17-PMF-009U.S. Department of Health & Human Services | National Institutes of Health (NIH) P30DK036836U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01DK124258U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01DK129850U.S. Department of Health & Human Services | National Institutes of Health (NIH) T32DK007260
6 · The paper itself

Abstract

VO

Indexed as

Adaptation, PhysiologicalDiet, KetogenicHyperglycemiaMitochondria, MuscleMuscle, SkeletalPhysical Conditioning, AnimalAnimalsBlood GlucoseMaleMiceMice, Inbred C57BLOxygen ConsumptionBlood Glucose

Identifiers

PMID41741431
PMCPMC12936107

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.