ArticleCell death discovery2026
Irisin inhibits adipogenic differentiation of bone marrow mesenchymal stem cells through the SIRT1/RANBP2/FTO signaling axis and protects against osteoporosis.
Article in Cell death discovery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Diet and Lipidomics Mediated Regulation of Mesenchymal Stem Cell Function: Diet, Omics and Stem Cell Connection.Biomolecules · 2026Review
- Myokines in exercise‑mediated bone homeostasis: Molecular signaling mechanisms and therapeutic implications for bone disorders (Review).International journal of molecular medicine · 2026Review
Corrections and comments
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Authors and funding
10 authors.
Funding
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Abstract
Abnormal bone marrow obesity caused by the conversion of bone marrow mesenchymal stem cells (BMMSCs) from osteoblast to adipocyte differentiation is one of the significant contributors to age and menopause-related osteoporosis (OP) development. Irisin, one of the myokines, has been reported to be involved in skeletal metabolic diseases, providing new insights into the pathogenesis of OP. However, the specific mechanism of irisin in adipogenic differentiation of BMMSCs has not been thoroughly explored. Clinical data from this study confirmed the expression of irisin in OP and its clinical significance. In addition, irisin inhibited adipogenic differentiation of BMMSCs in vitro and reduced bone loss and abnormal bone marrow obesity in ovariectomized (OVX) mice. Mechanistically, SIRT1 was identified as a downstream target of irisin, and activated SIRT1 inhibited the expression of FTO through deacetylating RANBP2, which downregulated the stability and expression of PPARγ. The current study revealed a novel molecular mechanism by which irisin mediated BMMSCs adipogenesis through the SIRT1/RANBP2/FTO signaling axis.
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Registered trials
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