SynthesisTranslational psychiatry2026
The predictive value of polygenic risk scores for depression in gene-environment interaction studies: a systematic review.
Synthesis in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Diet quality and depressive symptoms in older adults, assessing the effect modification by genetic predisposition and low-grade inflammation: a target trial emulation.Molecular psychiatry · 2026Article
- The long reach of childhood income inequality: a multinational twin study of gene-environment interplay on adult depressive symptoms.Psychological medicine · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundAccording to the diathesis-stress model, genetic liability and environmental exposures interact in the pathogenesis of depression. Polygenic risk scores for depression (PRS
methodsBased on a preregistered, systematic literature search according to PRISMA guidelines, 56 studies were considered for qualitative analysis. Respective studies investigated a broad range of adverse and protective environmental exposures across the lifespan, e.g., trauma, stressful life events, social environments and (un)healthy lifestyle factors, using cross-sectional and longitudinal designs.
resultsWhile most studies reported significant main effects of an individual's PRS
conclusionTwo general conclusions can be drawn from this review. First, PRS
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Registered trials
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