Evidence map›Paper›PMID 41741401›Full record

ArticlePalliative & supportive care2026

It's all about the relationship: The caregiver experience of supporting a person with advanced cancer going through an LSD microdosing trial.

Fiona Cottam, Alesha Wells, Cerys Clayden, Lisa Reynolds

Abstract read
In one paragraph

Article in Palliative & supportive care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Fiona CottamDepartment of Psychological Medicine, Faculty of Medical and Health Sciences, University of Auckland, Grafton, Auckland, New Zealand.
Alesha WellsDepartment of Psychological Medicine, Faculty of Medical and Health Sciences, University of Auckland, Grafton, Auckland, New Zealand.
Cerys ClaydenDepartment of Psychological Medicine, Faculty of Medical and Health Sciences, University of Auckland, Grafton, Auckland, New Zealand.ORCID https://orcid.org/0009-0004-9115-8432
Lisa ReynoldsDepartment of Psychological Medicine, Faculty of Medical and Health Sciences, University of Auckland, Grafton, Auckland, New Zealand.ORCID https://orcid.org/0000-0002-9609-2135

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe objectives of this research were to investigate the hopes, beliefs, perceptions, and experience of caregivers for advanced cancer patients undergoing a trial investigating a psychedelic-assisted therapy.

methodsSemi-structured interviews asked 15 caregivers about their experience at baseline and 1 month after their close associate had completed treatment in a feasibility trial where participants were randomized to receive either lysergic acid diethylamide (LSD) microdoses or placebo alongside meaning-centered psychotherapy (MCP). Blinded to condition, reflexive thematic analysis was used to analyze interview transcripts.

resultsThis study demonstrates the importance of bidirectional influences between caregiver and patient; the experience of one influences the experience of both. Caregivers were generally supportive of their close associate participating in a psychedelic-assisted trial, although some admitted hesitancy in them taking part. Caregivers described a desire to make the most of now, referring to the role of LSD microdose-assisted MCP as a means of accessing hope, improving the dyad relationship, and reducing existential distress. SIGNIFICANCE OF

resultsParticipation in trials investigating psychedelic-assisted MCP may offer hope for patients and their caregivers. Given the bidirectional relationship in wellbeing between cancer dyads, caregivers should be included alongside patients in such trials.

Indexed as

CaregiversLysergic Acid DiethylamideNeoplasmsAdultAgedFemaleHallucinogensHumansInterviews as TopicMaleMiddle AgedQualitative ResearchHallucinogensLysergic Acid DiethylamideCancer caregiverscaregiver-patient relationshipdistressdyadLSDMCPmicrodosing

Identifiers

PMID41741401
PMCPMC13166546

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.