ArticlePacing and clinical electrophysiology : PACE2026
Sex-Based Differences in Left Bundle Branch Capture During Left Bundle Branch Area Pacing.
Article in Pacing and clinical electrophysiology : PACE, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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14 authors.
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Abstract
objectiveTo identify sex-based differences in meeting left bundle branch (LBB) capture criteria on postimplant ECGs.
backgroundDespite differences in QRS duration (QRSd) between males and females, no sex-based criteria have been established for defining LBB capture during LBB area pacing (LBBAP).
methodsPatients aged >18 y.o. with a pacing indication and dual-chamber LBBAP pacemaker implantation from 2020 to 2023 were studied. Baseline and postoperative day 1 (POD1) ECGs were assessed for electrical dyssynchrony (QRS-area, sum-absolute integral of QRS-T (SAI QRS-T)), with LBB capture defined based on R-wave peak times (RWPT) per the EHRA 2023 Consensus algorithm.
resultsThe cohort included 222 patients (143 males/79 females, age 74.5±1.1 years, LVEF 53.7±0.4%). Baseline QRSd was significantly shorter among females than males (median 122 ms [90,134] vs 126 ms [102,146]; p = 0.018). LBB capture criteria were met in 83 (58.0%) male and 56 (70.9%) female patients (p = 0.058). Baseline and POD1 dyssynchrony were similar between sexes. However, RWPTs measured in leads V
conclusionsFemales with LBB capture exhibit shorter V
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