ArticleThe Journal of international medical research2026
A study on the correlation between DNA methylation and protein expression levels of
Article in The Journal of international medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
PurposeTo investigate the association between Syndecan-2 gene methylation and protein expression dynamics in colorectal cancer and evaluate its clinicopathological significance.MethodsWe analyzed 197 tissues (96 colorectal cancer, 64 adenoma, and 37 normal tissues). Syndecan-2 methylation was quantified using quantitative methylation-specific polymerase chain reaction, and protein expression was evaluated via immunohistochemistry.ResultsSyndecan-2 methylation frequency was significantly higher in colorectal cancer (81.25%) and adenoma (64.06%) than in normal (5.41%) tissues. It showed high diagnostic accuracy for colorectal cancer (area under the curve = 0.88). Although methylation status was unrelated to most clinical parameters, higher methylation levels were correlated with poor tumor differentiation (
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