Evidence map›Paper›PMID 41741005›Full record

SynthesisEuropean respiratory review : an official journal of the European Respiratory Society2026

Physical inactivity in chronic airways disease: an important candidate in the treatable traits paradigm.

Benjamin Griffiths, Reem Alajmi, Ian J Clifton, Rebecca J Birch, Daniel Peckham, Oliver J Price

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in European respiratory review : an official journal of the European Respiratory Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Benjamin GriffithsSchool of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, UK.ORCID https://orcid.org/0000-0001-7454-3567
Reem AlajmiSchool of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, UK.
Ian J CliftonDepartment of Respiratory Medicine, Leeds Teaching Hospitals NHS Trust, Leeds, UK.ORCID https://orcid.org/0000-0002-9758-9506
Rebecca J BirchLeeds Institute of Medical Research, University of Leeds, Leeds, UK.
Daniel PeckhamDepartment of Respiratory Medicine, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Oliver J PriceSchool of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, UK o.price1@leeds.ac.uk.ORCID https://orcid.org/0000-0001-8596-4949

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPhysical inactivity is a common and potentially modifiable trait in individuals with chronic airways disease, yet disease-specific physical activity profiles and clinical determinants remain poorly defined.

methodsWe conducted a systematic review and meta-analysis in accordance with PRISMA guidelines to characterise physical activity profiles across the spectrum of chronic airways disease. Studies reporting objectively measured physical activity in adults with COPD, asthma, noncystic fibrosis bronchiectasis, cystic fibrosis or primary ciliary dyskinesia were included. Primary outcomes were daily step count and time spent in moderate-to-vigorous physical activity (MVPA). Univariate and multivariate regression analysis was used to explore disease-specific determinants and associations with established clinical outcome measures.

results236 studies (353 cohorts, n=25 278 with chronic airways disease) met the eligibility criteria. The mean daily step count was 5494 (95% CI 5152-5636) and MVPA was 48.2 min·day

conclusionPhysical inactivity is highly prevalent across chronic airways diseases and is consistently associated with established clinical outcome measures. These findings highlight the clinical relevance of objective physical activity assessment and support its consideration within the treatable traits framework as part of routine disease evaluation and management.

Indexed as

AsthmaExerciseKartagener SyndromeLungPulmonary Disease, Chronic ObstructiveSedentary BehaviorActigraphyAdultAgedChronic DiseaseCystic FibrosisExercise ToleranceFemaleForced Expiratory VolumeHumansMale

Identifiers

PMID41741005
PMCPMC12933259

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.