Evidence map›Paper›PMID 41740737›Full record

ArticleMolecular & cellular proteomics : MCP2026

An Integrative Proteotranscriptomics Approach Reveals New ADAM9 Substrates and Downstream Pathways.

Congyu Lu, Xiaolu Xu, Neha Sindhu, Jessica Rainey, Yuhan Zhang, Shawn W Polson, Jing Qiu, Shuo Wei

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular & cellular proteomics : MCP, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Congyu LuDepartment of Biological Sciences, University of Delaware, Newark, Delaware, USA; Center for Bioinformatics and Computational Biology, University of Delaware, Newark, Delaware, USA.
Xiaolu XuDepartment of Biological Sciences, University of Delaware, Newark, Delaware, USA.
Neha SindhuDepartment of Biological Sciences, University of Delaware, Newark, Delaware, USA; Center for Bioinformatics and Computational Biology, University of Delaware, Newark, Delaware, USA.
Jessica RaineyDepartment of Biological Sciences, University of Delaware, Newark, Delaware, USA.
Yuhan ZhangDepartment of Electrical and Computer Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Shawn W PolsonCenter for Bioinformatics and Computational Biology, University of Delaware, Newark, Delaware, USA; Department of Computer and Information Sciences, University of Delaware, Newark, Delaware, USA.
Jing QiuCenter for Bioinformatics and Computational Biology, University of Delaware, Newark, Delaware, USA; Department of Applied Economics and Statistics, University of Delaware, Newark, Delaware, USA.
Shuo WeiDepartment of Biological Sciences, University of Delaware, Newark, Delaware, USA; Center for Bioinformatics and Computational Biology, University of Delaware, Newark, Delaware, USA. Electronic address: swei@udel.edu.

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI Shawn W Polson · 2012 to 2026
$67.2M
Subproject Title: Clinical Research Education, Mentoring and Career Development CoreU54GM104941 · NIGMS · UNIVERSITY OF DELAWARE · PI Gregory E Hicks · 2013 to 2026
$60.5M
This renovation project will create over 1455 sq. ft. of state- of-the-art reseaP20GM104316 · NIGMS · UNIVERSITY OF DELAWARE · PI FOX, JOSEPH M · 2014 to 2024
$26.8M
Supplement for Google cloud build-outR24GM137786 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Alan Tackett · 2020 to 2026
$15.4M
Mechanisms of Neural Crest Induction and Craniofacial DisordersR01DE029802 · NIDCR · UNIVERSITY OF DELAWARE · PI WEI, SHUO · 2020 to 2024
$1.8M
ADAM-ephrin interactions in cell signaling and adhesionR01GM163327 · NIGMS · UNIVERSITY OF DELAWARE · PI Shuo Wei · 2026 to 2026
$1.4M
NIDCR NIH HHS R01 DE029802NIGMS NIH HHS P20 GM103446NIGMS NIH HHS P20 GM104316NIGMS NIH HHS R01 GM163327NIGMS NIH HHS R24 GM137786NIGMS NIH HHS U54 GM104941
6 · The paper itself

Abstract

A Disintegrin And Metalloproteinase 9 (ADAM9) is a cell-surface protease that can shed the ectodomain of membrane protein substrates. Dysregulated ADAM9 activity has been implicated in several diseases, such as solid tumors, autoimmunity, inflammatory diseases, and coronavirus disease 2019. Despite its importance, the substrates and targets of ADAM9 in normal and pathological processes are poorly understood. Here, we developed an integrative proteotranscriptomics approach to systematically identify the transcriptional and post-transcriptional targets of ADAM9 in HCT116 cells, which have a stable diploid karyotype suitable for omics analyses. Using this approach, we uncovered major signaling pathways downstream of ADAM9, including the oncogenic mechanistic target of rapamycin pathway and the tumor suppressor Forkhead Box O pathway. We also identified several direct and indirect substrates for ADAM9, which may mediate the pathophysiological roles of this protease. This study provides new mechanistic insights into the function of ADAM9 as well as a method that can be applied to other membrane proteases.

Indexed as

ADAM ProteinsMembrane ProteinsProteomicsCell Line, TumorForkhead Box Protein O1HumansMultiomicsSignal TransductionSubstrate SpecificityTOR Serine-Threonine KinasesADAM9 protein, humanADAM ProteinsForkhead Box Protein O1FOXO1 protein, humanMembrane ProteinsTOR Serine-Threonine KinasesADAM9ectodomain sheddingFOXOmTORproteotranscriptomics

Identifiers

PMID41740737
PMCPMC13054030

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.