Evidence map›Paper›PMID 41740624›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2026

Pyelonephritis decreases serum cholesterol and mitigates atherosclerosis severity despite systemic inflammation.

Lena Possenriede, Georg W Sendtner, Peyman Falahat, Uta Scheidt, Julia Miranda, Jessica Schmitz, Jan Hinrich Bräsen, Sibylle von Vietinghoff

Abstract read
PubMed Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The neutrophil-renal-cholesterol axis: a new link between infection and atherosclerosis.American journal of physiology. Heart and circulatory physiology · 2026
    Article
  2. Monocyte Chemokines Enhance Atherosclerotic Plaque Necrosis After Bacterial Kidney Infection.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Lena PossenriedeNephrology Section, Medical Clinic 1, University Hospital Bonn, Rheinische Friedrich-Wilhelms Universität, Bonn, Germany.
Georg W SendtnerNephrology Section, Medical Clinic 1, University Hospital Bonn, Rheinische Friedrich-Wilhelms Universität, Bonn, Germany.ORCID 0000-0003-1472-7254
Peyman FalahatNephrology Section, Medical Clinic 1, University Hospital Bonn, Rheinische Friedrich-Wilhelms Universität, Bonn, Germany.
Uta ScheidtNephrology Section, Medical Clinic 1, University Hospital Bonn, Rheinische Friedrich-Wilhelms Universität, Bonn, Germany.ORCID 0009-0006-2196-0483
Julia MirandaNephrology Section, Medical Clinic 1, University Hospital Bonn, Rheinische Friedrich-Wilhelms Universität, Bonn, Germany.
Jessica SchmitzNephropathology Unit, Institute for Pathology, Hannover Medical School, Hannover, Germany.ORCID 0000-0001-9843-7339
Jan Hinrich BräsenNephropathology Unit, Institute for Pathology, Hannover Medical School, Hannover, Germany.ORCID 0000-0002-2863-3067
Sibylle von VietinghoffNephrology Section, Medical Clinic 1, University Hospital Bonn, Rheinische Friedrich-Wilhelms Universität, Bonn, Germany.ORCID 0000-0002-3217-5433

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypercholesterolemia and inflammation are main causes of cardiovascular disease. Urinary tract infections are common and frequently recur. We here tested how pyelonephritis affects atherosclerotic plaque development and lipid levels. LDL receptor-deficient (

Indexed as

Aortic DiseasesAtherosclerosisCholesterolEscherichia coli InfectionsInflammationPyelonephritisAnimalsDisease Models, AnimalFemaleHumansInflammation MediatorsKidneyMaleMiceMice, Inbred C57BLMice, KnockoutCholesterolInflammation MediatorsReceptors, LDLatherosclerosisbacterial infectionkidneyneutrophils

Identifiers

PMID41740624

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.