Observational studySpine2026
Nationwide Retrospective Analysis of Early Complications After Adult Spinal Deformity Surgery: Insights From the Japanese Spinal Instrumentation Society Database Registry.
Observational study in Spine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The trial behind it
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
designRetrospective nationwide registry-based observational study.
objectiveTo determine the incidence of and factors associated with early complications following surgery for adult spinal deformity (ASD). SUMMARY OF BACKGROUND DATA: Complications after ASD surgery contribute to morbidity, mortality, and health care costs. Prior studies were limited by small sample sizes and incomplete surgical information. The Japanese Spinal Instrumentation Society database (JSIS-DB) includes detailed instrumentation data, enabling a robust secondary analysis of perioperative factors. MATERIALS AND
methodsWe analyzed JSIS-DB data from patients undergoing ASD surgery involving the fusion of three or more vertebrae between 2018 and 2022. Demographics, comorbidities, and surgical variables [fusion length, osteotomy, interbody fusion type, minimally invasive surgery (MIS), staged procedures, navigation, and neuromonitoring] were assessed. The primary endpoint was ultra-early perioperative complications within two weeks, classified as major (mortality, massive bleeding, neurological, cardiopulmonary, or infectious events) or minor (dural injury, delirium, or urinary tract infection). Multivariable logistic regression was used to identify the associated factors.
resultsAmong 3193 patients (mean age 60.8 yr), the overall complication rate was 28.5%, including 25.4% with major complications and 0.1% with mortality. Increased risk was associated with operative time >5 hours [adjusted odds ratio (aOR) 4.40; 95% CI: 3.60-5.47], fusion >5 levels (aOR: 1.51; 95% CI: 1.20-1.91), posterior/transforaminal interbody fusion (PLIF/TLIF) (aOR: 1.47; 95% CI: 1.20-1.79), and three-column osteotomy (3CO) (aOR: 3.50; 95% CI: 2.21-5.53). Reduced risk was associated with adult idiopathic scoliosis (aOR: 0.48; 95% CI: 0.37-0.63), staged surgery (aOR: 0.24; 95% CI: 0.18-0.32), lateral lumbar interbody fusion (LLIF) (aOR: 0.74; 95% CI: 0.58-0.95), and MIS (aOR: 0.65; 95% CI: 0.49-0.86). Respiratory complications, massive bleeding, neurological deficits, surgical site infections, and proximal junctional kyphosis were associated with prolonged hospitalization (>30 d).
conclusionsThis nationwide registry analysis demonstrated that prolonged operative time, long fusion, PLIF/TLIF, and 3CO increase the early complication risk after ASD surgery, whereas staged surgery, LLIF, and MIS are protective. LEVEL OF EVIDENCE: Level III-retrospective cohort study.
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