Evidence map›Paper›PMID 41740528›Full record

ArticleClinics (Sao Paulo, Brazil)2026

Elective single embryo transfer in in vitro fertilization cycles with or without preimplantation genetic testing using next-generation sequencing: A randomized clinical trial.

Pedro Felipe Magalhães Peregrino, Carlos Augusto Z Nissel, Patricia Florido, Mayara Satiko Nakano, Marcos de Lorenzo Messina, José Maria Soares Júnior, Edmund Chada Baracat, Pedro Augusto Araujo Monteleone

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In one paragraph

Article in Clinics (Sao Paulo, Brazil), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pedro Felipe Magalhães PeregrinoDisciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Hospital das Clínicas da Faculdade de Medicina da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil. Electronic address: pfmperegrino67@yahoo.com.br.
Carlos Augusto Z NisselDisciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Hospital das Clínicas da Faculdade de Medicina da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
Patricia FloridoDisciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Hospital das Clínicas da Faculdade de Medicina da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
Mayara Satiko NakanoDisciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Hospital das Clínicas da Faculdade de Medicina da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
Marcos de Lorenzo MessinaDisciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Hospital das Clínicas da Faculdade de Medicina da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
José Maria Soares JúniorDisciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Hospital das Clínicas da Faculdade de Medicina da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
Edmund Chada BaracatDisciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Hospital das Clínicas da Faculdade de Medicina da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
Pedro Augusto Araujo MonteleoneDisciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Hospital das Clínicas da Faculdade de Medicina da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPreimplantation Genetic Testing (PGT-A) has been increasingly used in IVF to improve embryo selection. However, its clinical utility in patients with a good prognosis remains debated. There is a lack of robust scientific evidence about the benefits of preimplantation genetic testing Next-Generation Sequencing (NGS) on the clinical pregnancy and live birth rates in good-prognosis IVF patients undergoing elective Single Embryo Transfer (eSET) testing.

objectiveTo compare the clinical pregnancy rate after IVF treatment in patients with a good prognosis between groups that receive the transfer of a single embryo with or without pre-implantation genetic embryo analysis.

methodsThis work was a prospective randomized clinical study that evaluated 206 patients to compare the clinical pregnancy rate after the first elective transfer of an embryo, associated or not with pre-implantation genetic embryo analysis using Next-Generation Sequencing (NGS). Patients were randomized into groups: SET group ‒ patients undergoing the transfer of a single embryo (eSET, elective Single Embryo Transfer) without embryo genetic analysis (SET group, n = 103); and NGS + SET group ‒ patients undergoing eSET with embryo genetic analysis (NGS + SET group, n = 103).

resultsThe clinical pregnancy rate after the first transfer was similar between the two groups (SET: 76.7 % and NGS + SET: 79.6 %; p = 0.613). There was also no statistical difference in live birth rates or abortion rates between the groups analyzed.

conclusionThis clinical trial suggests no significant improvement in the embryo genetic analysis in IVF treatments for infertile couples with a good prognosis.

Indexed as

In vitro fertilizationNext-generation sequencingPre-implantation genetic diagnosisReproductive medicineSingle embryo transfer pregnancy rate

Identifiers

PMID41740528
PMCPMC12973516

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