ArticleMultiple sclerosis and related disorders2026
Cross sectional analyses indicated that body fat distribution was not associated with performance-based and self-reported outcomes among ambulatory people with multiple sclerosis.
Article in Multiple sclerosis and related disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundObesity is cited as a relevant factor in multiple sclerosis (MS). To date, there is inconsistent evidence regarding the relationship between total body fat and frequently studied outcomes in MS. Body fat distribution, or the location of adipose tissue and depots within the body, may represent a biologically meaningful correlate of MS-related outcomes. PURPOSE: This exploratory study assessed whether dual-energy X-ray absorptiometry (DXA)-based body fat distribution metrics were associated with performance-based and self-reported outcomes of MS.
methodsFifty-seven ambulatory adults with MS underwent DXA to quantify visceral and subcutaneous adipose tissue; android- and gynoid- % fat mass; and android/gynoid ratio. Outcomes included performance-based (Timed Up and Go, Timed 25-Foot Walk, Six-Minute Walk) and self-reported assessments (Hospital Anxiety and Depression Scale anxiety and depression [HADS-D] sub-scales), Multiple Sclerosis Impact Scale physical [MSIS Physical] and psychological domains, Fatigue Severity Scale, and the short form of the McGill Pain Questionnaire). Spearman correlation assessed bivariate and partial (controlling for sex and age) associations.
resultsCorrelations between body fat distribution metrics and performance-based and self-reported outcomes were generally small and not statistically significant. Gynoid % fat mass correlated with depressive symptoms (HADS-D: r
conclusionOur results did not support an association between body fat distribution and frequently studied MS-related outcomes. This aligns with research suggesting a limited role of adiposity and MS-related outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.