Evidence map›Paper›PMID 41740201›Full record

ArticleMolecular pharmacology2026

UCM-A86 is a selective positive allosteric modulator of GluN1/GluN3 NMDA receptors.

Avery J Benton, Mia R Johns, Emil Diamant, Nirvan Rouzbeh, Valdemar P Sørensen, Carly M Anderson, Davide Secci, Zhucheng Zhang, Andrew R Rau, Rasmus P Clausen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Avery J BentonCenter for Structural and Functional Neuroscience, Center for Biomolecular Structure and Dynamics, Division of Biological Sciences, University of Montana, Missoula, Montana.
Mia R JohnsCenter for Structural and Functional Neuroscience, Center for Biomolecular Structure and Dynamics, Division of Biological Sciences, University of Montana, Missoula, Montana.
Emil DiamantCenter for Structural and Functional Neuroscience, Center for Biomolecular Structure and Dynamics, Division of Biological Sciences, University of Montana, Missoula, Montana; Department for Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Nirvan RouzbehCenter for Structural and Functional Neuroscience, Center for Biomolecular Structure and Dynamics, Division of Biological Sciences, University of Montana, Missoula, Montana.
Valdemar P SørensenCenter for Structural and Functional Neuroscience, Center for Biomolecular Structure and Dynamics, Division of Biological Sciences, University of Montana, Missoula, Montana; Department for Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Carly M AndersonCenter for Structural and Functional Neuroscience, Center for Biomolecular Structure and Dynamics, Division of Biological Sciences, University of Montana, Missoula, Montana.
Davide SecciDepartment for Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Zhucheng ZhangDepartment for Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Andrew R RauCenter for Structural and Functional Neuroscience, Center for Biomolecular Structure and Dynamics, Division of Biological Sciences, University of Montana, Missoula, Montana.
Rasmus P ClausenDepartment for Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: rac@sund.ku.dk.
Kasper B HansenCenter for Structural and Functional Neuroscience, Center for Biomolecular Structure and Dynamics, Division of Biological Sciences, University of Montana, Missoula, Montana. Electronic address: kasper.hansen@mso.umt.edu.

Funding

Research Core (Developmental Research Project Program)P20GM103474 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI Ann Therese Bertagnolli · 2012 to 2026
$60.0M
Surveillance genome sequencing to detect SARS-CoV-2 virus variants in MontanaP30GM140963 · NIGMS · UNIVERSITY OF MONTANA · PI BOWLER, BRUCE E · 2021 to 2025
$6.9M
Structural and functional investigation of negative allosteric NMDA receptor modulationR01NS097536 · NINDS · UNIVERSITY OF MONTANA · PI Kasper Boe Hansen · 2016 to 2026
$3.4M
Physiology and pharmacology of GluN3-containing NMDA receptorsR01NS116055 · NINDS · UNIVERSITY OF MONTANA · PI HANSEN, KASPER BOE · 2021 to 2025
$1.8M
NIGMS NIH HHS P20 GM103474NIGMS NIH HHS P30 GM140963NINDS NIH HHS R01 NS097536NINDS NIH HHS R01 NS116055
6 · The paper itself

Abstract

NMDA receptors are ionotropic glutamate receptors that mediate excitatory neurotransmission in the central nervous system where they play critical roles in normal and pathological brain functions and neurodevelopment. Glutamate/glycine-activated GluN2-containing NMDA receptors (GluN1/GluN2) have been extensively studied, whereas the physiological roles and pharmacology of glycine-activated GluN3-containing receptors (GluN1/GluN3) remain less understood. Although GluN1/GluN3 receptors exhibit unique functional properties and play distinct roles in neuronal development and synapse maturation, studies of their precise roles in neurophysiology and circuit function are impeded by limited availability of GluN3-selective pharmacological tools. This study explores UCM-A86, a novel GluN3-selective positive allosteric modulator, with EC

Indexed as

Nerve Tissue ProteinsReceptors, N-Methyl-D-AspartateAllosteric RegulationAnimalsGlycineHEK293 CellsHumansMiceXenopus laevisGlycineNerve Tissue ProteinsReceptors, N-Methyl-D-AspartateAllosteric modulationDrug discoveryIonotropic glutamate receptorsLigand-gated ion channelsNeuropharmacologySynaptic transmission

Identifiers

PMID41740201
PMCPMC13095639

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.