Evidence map›Paper›PMID 41740085›Full record

ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2026

Optimizing Haploidentical Donor Selection for Pediatric Hematopoietic Cell Transplant.

Nicole Liberio, Mariam Allbee-Johnson, Kwang Woo Ahn, Amy Moskop, Rachel Phelan, Bronwen E Shaw, Kristin M Page, Kirk R Schultz, Christine L Phillips, Parinda A Mehta and 11 more

Abstract read
In one paragraph

Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Nicole LiberioDepartment of Pediatrics, Division of Pediatric Hematology/Oncology/Blood and Marrow Transplant, Medical College of Wisconsin, Milwaukee, WI.ORCID 0000-0002-0889-1253
Mariam Allbee-JohnsonCIBMTR (Center for International Blood and Marrow Transplant Research), Medical College of Wisconsin, Milwaukee, WI.
Kwang Woo AhnCIBMTR (Center for International Blood and Marrow Transplant Research), Medical College of Wisconsin, Milwaukee, WI.ORCID 0000-0003-4567-8037
Amy MoskopDepartment of Pediatrics, Division of Pediatric Hematology/Oncology/Blood and Marrow Transplant, Medical College of Wisconsin, Milwaukee, WI.ORCID 0000-0002-5110-004X
Rachel PhelanDepartment of Pediatrics, Division of Pediatric Hematology/Oncology/Blood and Marrow Transplant, Medical College of Wisconsin, Milwaukee, WI.ORCID 0000-0001-6041-5265
Bronwen E ShawCIBMTR (Center for International Blood and Marrow Transplant Research), Medical College of Wisconsin, Milwaukee, WI.ORCID 0000-0003-3317-1896
Kristin M PageDepartment of Pediatrics, Division of Pediatric Hematology/Oncology/Blood and Marrow Transplant, Medical College of Wisconsin, Milwaukee, WI.
Kirk R SchultzDepartment of Pediatric Hematology, Oncology and Bone Marrow Transplant, British Columbia's Children's Hospital, The University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0002-0001-6438
Christine L PhillipsDivision of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Parinda A MehtaDivision of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Muna QayedAflac Cancer and Blood Disorders Center, Emory University and Children's Healthcare of Atlanta, Atlanta, GA.ORCID 0000-0001-7689-343X
Akshay SharmaDepartment of Bone Marrow Transplantation and Cellular Therapy, St Jude Children's Research Hospital, Memphis, TN.ORCID 0000-0003-3281-2081
Amanda E LipsittSarah Cannon Pediatric Transplant and Cellular Therapy Program, Methodist Children's Hospital, San Antonio, TX.ORCID 0000-0002-3757-8493
Heather SymonsPediatric Blood and Marrow Transplant, Johns Hopkins School of Medicine, Baltimore, MD.
Javier Bolaños-MeadeThe Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Division of Hematologic Malignancies, Johns Hopkins School of Medicine, Baltimore, MD.
Sandhya KharbandaBenioff Children's Hospital, Division of Pediatric Allergy, Immunology & Bone Marrow Transplantation, University of California San Francisco, San Francisco, CA.
Christopher C DvorakBenioff Children's Hospital, Division of Pediatric Allergy, Immunology & Bone Marrow Transplantation, University of California San Francisco, San Francisco, CA.ORCID 0000-0002-6146-3952
Neena KapoorDivision of Hematology, Oncology and Blood & Marrow Transplantation, Children's Hospital, Los Angeles, CA.ORCID 0000-0002-3352-9651
Erin E DohertyDepartment of Pediatrics, Section of Hematology/Oncology/Stem Cell Transplantation, Baylor College of Medicine/Texas Children's Hospital, Houston, TX.
Rishikesh S ChavanDepartment of Pediatric Oncology, Children's Hospital of Orange County, Orange, CA.ORCID 0000-0001-5849-0960
Larisa BroglieDepartment of Pediatrics, Division of Pediatric Hematology/Oncology/Blood and Marrow Transplant, Medical College of Wisconsin, Milwaukee, WI.ORCID 0000-0002-1674-048X

Funding

Data Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2M
NCI NIH HHS U24 CA076518
6 · The paper itself

Abstract

purposeCritical guidance on selecting haploidentical donors for pediatric patients is lacking. It is unclear whether parents, siblings, and extended family affect acute and chronic graft-versus-host disease (aGVHD and cGVHD) differently.

methodsWe analyzed 1,069 pediatric (<19 years) recipients of hematopoietic cell transplant during 2013-2019. Primary end points were aGVHD frequency at 100 days and cumulative incidence of cGVHD at 2 years, assessed by donor age (<18 years, 18-35, >35 years) and donor relationship, with multivariable analysis.

resultsDonor age: Increased grade II-IV aGVHD occurred with older donors: >35 years (31%, odds ratio [OR], 1.7 [95% CI, 1.0 to 2.8];

conclusionDonors <18 years are associated with reduced aGVHD and cGVHD, whereas maternal donors are associated with increased cGVHD risk. For pediatric patients, sibling donors should be considered to reduce GVHD.

Indexed as

Donor SelectionGraft vs Host DiseaseHematopoietic Stem Cell TransplantationTransplantation, HaploidenticalAdolescentAdultAge FactorsChildChild, PreschoolFemaleHumansInfantMaleRisk FactorsSiblingsYoung Adult

Identifiers

PMID41740085
PMCPMC13162296

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.