Evidence map›Paper›PMID 41739905›Full record

ArticleScience translational medicine2026

Actin depolymerization promotes axon regeneration by restoring axonal mitochondrial transport in mouse models of optic neuropathy.

Liang Li, Xue Feng, Fang Fang, Jinyu Fei, Jenny Lu, Huiying Zhang, Michaela Dujava Ždímalová, Yuan Yuan, Ziming Luo, Haoliang Huang and 21 more

Abstract read
In one paragraph

Article in Science translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Actin disassembly triggers CNS myelin compaction and wrapping.bioRxiv : the preprint server for biology · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Liang LiSpencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA.ORCID 0000-0002-6292-5995
Xue FengSpencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA.
Fang FangSpencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA.
Jinyu FeiDepartment of Chemistry, Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0003-4013-8322
Jenny LuDepartment of Ophthalmology, University of California San Francisco, San Francisco, CA 94158, USA.ORCID 0009-0006-5976-949X
Huiying ZhangDepartment of Ophthalmology, University of California San Francisco, San Francisco, CA 94158, USA.
Michaela Dujava ŽdímalováDepartment of Cell Biology, Faculty of Science, Charles University, Prague 12800, Czechia.ORCID 0009-0003-2075-0626
Yuan YuanDepartment of Biology, Stanford University, Palo Alto, CA 94305, USA.
Ziming LuoSpencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA.ORCID 0000-0002-2843-7453
Haoliang HuangSpencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA.ORCID 0000-0002-6856-3956
Dong LiuSpencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA.ORCID 0000-0001-8941-0812
Fengwen HuangSpencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA.ORCID 0000-0002-3188-6559
Hao LiuSpencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA.ORCID 0000-0002-3255-2948
Yuyang ZengSpencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA.ORCID 0000-0003-0593-4542
Fuyun BianSpencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA.
Mingshen MaSpencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA.
In-Jee YouSpencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA.ORCID 0000-0002-6557-5337
Liang LiuSpencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA.
Xiaoqin YanSpencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA.
Mu LiSpencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA.
Yan LinSpencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA.ORCID 0009-0002-0360-4419
Qinghong XieSpencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA.
Arjun KrishSaratoga High School, Saratoga, CA 95070, USA.
Xin DuanDepartment of Ophthalmology, University of California San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0001-5260-8972
Jeffrey Louis GoldbergSpencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA.ORCID 0000-0002-1390-7360
Xiaoke ChenDepartment of Biology, Stanford University, Palo Alto, CA 94305, USA.ORCID 0000-0001-9032-9093
Marcus BraunInstitute of Biotechnology, Czech Academy of Sciences, BIOCEV, Vestec, Prague West 25250, Czechia.ORCID 0000-0003-2026-2238
Zdenek LanskyInstitute of Biotechnology, Czech Academy of Sciences, BIOCEV, Vestec, Prague West 25250, Czechia.ORCID 0000-0001-8474-053X
Ying HanDepartment of Ophthalmology, University of California San Francisco, San Francisco, CA 94158, USA.
Ruobo ZhouDepartment of Chemistry, Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0001-8628-0282
Yang HuSpencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA.ORCID 0000-0002-7980-1649

Funding

Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2017 to 2026
$8.0M
Elucidating Neuron-Intrinsic Molecular Mechanisms of Optic Nerve RegenerationR01EY024932 · NEI · TEMPLE UNIV OF THE COMMONWEALTH · PI Yang Hu · 2015 to 2026
$4.8M
Mechanisms Underlying Type II Cadherin Guided Assembly of Retinal CircuitsR01EY030138 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Xin Duan · 2020 to 2026
$3.2M
In Vivo Function and Metabolism Evaluation of Glaucomatous RGCs by Two-Photon Scanning Laser OphthalmologyR01EY034353 · NEI · STANFORD UNIVERSITY · PI Yang Hu, Hao F Zhang · 2023 to 2026
$2.7M
Optineurin dysfunction induces neurodegeneration in normal tension glaucoma by a novel molecular mechanismR01EY032518 · NEI · STANFORD UNIVERSITY · PI Yang Hu · 2022 to 2026
$2.7M
Deciphering the functional role of actin-spectrin-based membrane skeleton in subcellular compartmentalization of signaling proteins and cell signal transductionR35GM142973 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI ZHOU, RUOBO · 2021 to 2025
$2.2M
Developing ER Stress Chemical Modulators as Neuroprotectants for GlaucomaR01EY036943 · NEI · STANFORD UNIVERSITY · PI Yang Hu · 2025 to 2026
$1.0M
NEI NIH HHS P30 EY026877NEI NIH HHS R01 EY024932NEI NIH HHS R01 EY030138NEI NIH HHS R01 EY032518NEI NIH HHS R01 EY034353NEI NIH HHS R01 EY036943NIGMS NIH HHS R35 GM142973
6 · The paper itself

Abstract

Adult mammalian central nervous system (CNS) axons do not spontaneously regenerate after injury. We recently identified multiple genes that promote optic nerve regeneration, protect retinal ganglion cell (RGC) somata and axons, and preserve visual function in mouse glaucoma models. Here, we investigated the downstream molecular mechanisms driving the regenerative and neuroprotective effects of the actin depolymerization molecule gelsolin (

Identifiers

PMID41739905
PMCPMC13283034

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.