Evidence map›Paper›PMID 41739901›Full record

ArticleScience translational medicine2026

A systems immunology approach reveals divergent immune profiles of RSV and SARS-CoV-2 infections in infants.

Asa Thibodeau, Asuncion Mejias, Djamel Nehar-Belaid, Radu Marches, Zhaohui Xu, Giray Eryilmaz, Steven Z Josefowicz, Bart Jones, Marie Wehenkel, Silke Paust and 4 more

Abstract read
In one paragraph

Article in Science translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Unique nasal cell states induced by common pediatric respiratory viruses.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Asa ThibodeauJackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.ORCID 0000-0003-2421-4225
Asuncion MejiasDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-5983-8006
Djamel Nehar-BelaidJackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.ORCID 0000-0001-6002-5021
Radu MarchesJackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
Zhaohui XuDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0003-0645-1737
Giray EryilmazJackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.ORCID 0000-0003-3599-5207
Steven Z JosefowiczDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA.ORCID 0000-0001-7453-779X
Bart JonesDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0009-0002-1768-2098
Marie WehenkelDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-8103-221X
Silke PaustJackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.ORCID 0000-0002-0526-3999
Virginia PascualDrukier Institute for Children's Health and Department of Pediatrics, Weill Cornell Medicine, New York, NY 10021, USA.ORCID 0000-0002-2274-7979
Jacques BanchereauJackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.ORCID 0000-0003-3535-7221
Octavio RamiloDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-0565-5239
Duygu UcarJackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.ORCID 0000-0002-9772-3066

Funding

Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI Paul Robson · 1985 to 2026
$61.9M
A deep longitudinal analysis of next generation influenza vaccines in older adultsU01AI165452 · NIAID · JACKSON LABORATORY · PI Adolfo Garcia-Sastre, GEORGE A KUCHEL · 2022 to 2026
$9.0M
High Precision System Analysis of Infant Immune ResponsesU01AI131386 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI RAMILO, OCTAVIO, SANCHEZ, PABLO J · 2017 to 2021
$6.3M
NCI NIH HHS P30 CA034196NIAID NIH HHS U01 AI131386NIAID NIH HHS U01 AI165452
6 · The paper itself

Abstract

Respiratory syncytial virus (RSV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in infants differ substantially in their clinical presentations and outcomes. RSV is the leading cause of severe lower respiratory tract infection in infants, whereas SARS-CoV-2 infections are typically milder and do not necessarily involve the lower respiratory tract. To uncover immune mechanisms associated with these differences, we analyzed blood samples from infants (median age, 2.3 months) infected with RSV (

Identifiers

PMID41739901
PMCPMC13317485

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.