Evidence map›Paper›PMID 41739716›Full record

ArticleChemistry & biodiversity2026

Unveiling the Molecular Profile and Antiviral Potential of Costus arabicus L. Against Zika Virus.

Alice Rhelly V Carvalho, José Diogo E Reis, Ariane Coelho Ferraz, Marília Bueno da Silva Menegatto, Juliana da C Lopes, Sônia das G S R Pamplona, Milton N da Silva, Cintia Lopes de Brito Magalhães, Paulo Wender P Gomes, Consuelo Yumiko Yoshioka E Silva

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alice Rhelly V CarvalhoBiodiversity and Medicinal Chemistry Group, School of Pharmaceutical Sciences of Ribeirão Preto (FCFRP), University of São Paulo, Ribeirão Preto, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-1042-845X
José Diogo E ReisAmazon Integrated Metabolomics Center, Institute of Exact and Natural Sciences, Federal University of Pará, Belém, Pará, Brazil.
Ariane Coelho FerrazBiological Sciences Post-Graduation Program, Center for Research in Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil.
Marília Bueno da Silva MenegattoBiological Sciences Post-Graduation Program, Center for Research in Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil.
Juliana da C LopesFaculty of Forestry Engineering, Institute of Agrarian Sciences, Federal Rural University of Amazônia, Belém, Brazil.
Sônia das G S R PamplonaAmazon Integrated Metabolomics Center, Institute of Exact and Natural Sciences, Federal University of Pará, Belém, Pará, Brazil.
Milton N da SilvaAmazon Integrated Metabolomics Center, Institute of Exact and Natural Sciences, Federal University of Pará, Belém, Pará, Brazil.
Cintia Lopes de Brito MagalhãesBiological Sciences Post-Graduation Program, Center for Research in Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil.
Paulo Wender P GomesAmazon Integrated Metabolomics Center, Institute of Exact and Natural Sciences, Federal University of Pará, Belém, Pará, Brazil.
Consuelo Yumiko Yoshioka E SilvaAmazon Integrated Metabolomics Center, Institute of Exact and Natural Sciences, Federal University of Pará, Belém, Pará, Brazil.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 155028/2022-7
6 · The paper itself

Abstract

Widely used in Brazilian folk medicine, Costus arabicus L. (Canarana) is a herbaceous plant with promising pharmacological potential. Here, we profile the molecular composition of extracts from different plant organs and evaluate their in vitro activity against Zika virus (ZIKV). Ethanolic and aqueous extracts from leaves, stems, and roots were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) for metabolite assignment. In vitro antiviral activity was assessed against Zika, Chikungunya, and Oropouche viruses. Forty-five compounds were annotated, including amino acids, flavones, flavonols, glycosylated flavonoids, lignans, lipids, phenolic acids, steroidal saponins, and xanthones. The ethanolic extract demonstrated promising anti-ZIKV activity, with an EC

Indexed as

antiviral activityCostus arabicusflavonoidsliquid chromatography‐mass spectrometryphytochemical profileZika virus

Identifiers

PMID41739716
PMCPMC12935167

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.