Evidence map›Paper›PMID 41739645›Full record

ArticleCell reports2026

Modeling spastic paraplegia 4 with corticospinal motor neuron-enriched cortical organoids reveals genotype-phenotype and HDAC6-targetable pathology.

Neha Mohan, Skandha Ramakrishnan, Xiaohuan Sun, Ying Sun, Theresa Connors, Victor Chai, Emanuela Piermarini, Peter W Baas, James Cai, Mei Liu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Patient-derived forebrain cortical organoids reveal biphasic tau-MAP6-microtubule axis dysfunction in tauopathy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Neha MohanDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA.
Skandha RamakrishnanDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA.
Xiaohuan SunDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA.
Ying SunKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China.
Theresa ConnorsDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA.
Victor ChaiDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA.
Emanuela PiermariniDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA.
Peter W BaasDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA.
James CaiDepartment of Electrical and Computer Engineering, Texas A&M University, College Station, TX 77843, USA; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843, USA; Interdisciplinary Program of Genetics, Texas A&M University, College Station, TX 77843, USA.
Mei LiuKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China. Electronic address: liumei@ntu.edu.cn.
Liang QiangDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA. Electronic address: lq24@drexel.edu.

Funding

Elucidating the etiology of SPAST-based Hereditary Spastic ParaplegiaR01NS115977 · NINDS · DREXEL UNIVERSITY · PI QIANG, LIANG · 2021 to 2025
$1.8M
NINDS NIH HHS R01 NS115977
6 · The paper itself

Abstract

Spastic paraplegia 4 (SPG4), the most common form of hereditary spastic paraplegia, causes progressive gait deficiency due to corticospinal tract degeneration. SPG4 results from mutations in the SPAST gene, which encodes spastin, a microtubule-severing AAA-ATPase. To dissect genotype-phenotype relationships, we generated isogenic human induced pluripotent stem cell lines carrying either an SPAST missense (SPAST

Indexed as

Histone Deacetylase 6Motor NeuronsOrganoidsPyramidal TractsSpastic Paraplegia, HereditaryAnimalsAxonsDisease Models, AnimalGenotypeHumansHydroxamic AcidsIndolesInduced Pluripotent Stem CellsMiceMice, TransgenicMicrotubulesHDAC6 protein, humanHistone Deacetylase 6Hydroxamic AcidsIndolesSpastinSPAST protein, humantubastatin Acortical organoidscorticospinal motor neuronsCP: neuroscienceCP: stem cell researchhistone deacetylase 6human induced pluripotent stem cellsmicrotubule acetylationSPASTspastic paraplegia 4spastintubastatin A

Identifiers

PMID41739645
PMCPMC13076005

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.