Differential endopeptidase requirements during adaptation to changing growth conditions in

Kelly Rosch, Upasana Basu, Samantha Lei, Jennifer Zheng, Sven van Teeffelen, Tobias Dörr

Abstract read

In one paragraph

Article in Microbiology (Reading, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

Update of
Differential endopeptidase requirements during adaptation to changing growth conditions in2025

5 · Who and what money

Authors and funding

6 authors.

Kelly RoschWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, USA.

Upasana BasuWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, USA.

Samantha LeiWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, USA.

Jennifer ZhengWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, USA.

Sven van TeeffelenDépartement de Microbiologie, Infectiologie, et Immunologie, Faculté de Médecine, Université de Montréal, Montréal, QC, Canada.

Tobias DörrWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, USA.

Funding

Understanding autolysin function in Gram-negative bacterial growth and morphogenesisR35GM161163 · NIGMS · CORNELL UNIVERSITY · PI Tobias Doerr · 2026 to 2026

$291k

NIGMS NIH HHS R35 GM161163

6 · The paper itself

Abstract

The bacterial cell wall is a covalently linked meshwork of peptidoglycan (PG) that helps maintain cell shape and prevents osmotic lysis. This structure must be flexible enough to accommodate transenvelope protein complexes, but strong enough to withstand high intracellular pressure. To elongate and divide, cells must remodel the cell wall through the concerted action of PG synthesis and degradation. Endopeptidases, a class of PG-degrading enzymes, facilitate cell growth by hydrolysing PG crosslinks.

Indexed as

Adaptation, PhysiologicalBacterial ProteinsEndopeptidasesVibrio choleraeCell WallMutationOsmolar ConcentrationPeptidoglycanBacterial ProteinsEndopeptidasesPeptidoglycanbeta-lactamcell wallendopeptidase (EP)hydrolaseosmolaritypeptidoglycan

Identifiers

PMID41739538

DOI10.1099/mic.0.001671

PMCPMC13293342

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.